2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. BMS-952048

BMS-952048 是 mGluR5 的正向变构调节剂，其 EC50 为 10 nM。

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BMS-952048

BMS-952048 Chemical Structure

CAS No. : 1375751-32-8

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BMS-952048 相关抗体

Top Publications Citing Use of Products

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BMS-952048 is a positive allosteric modulator of mGluR5 with an EC50 of 10 nM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
10 nM
Compound: 22; BMS-952048
Positive allosteric modulation of human mGluR5A transfected in HEK293 cells assessed as potentiation of L-glutamate-induced calcium release incubated for 10 mins by FLIPR assay
Positive allosteric modulation of human mGluR5A transfected in HEK293 cells assessed as potentiation of L-glutamate-induced calcium release incubated for 10 mins by FLIPR assay
[PMID: 27496211]
HEK293 EC50
> 3000 nM
Compound: 22; BMS-952048
Agonist activity at human mGluR5A transfected in HEK293 cells assessed as induction of calcium release by FLIPR assay
Agonist activity at human mGluR5A transfected in HEK293 cells assessed as induction of calcium release by FLIPR assay
[PMID: 27496211]
分子量

377.34

Formula

C21H13F2N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BMS-952048 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-9520481375751-32-8BMS952048BMS 952048mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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产品名称：
BMS-952048
目录号：
HY-123874
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