2. Immunology/Inflammation
  3. Interleukin Related
  4. BMS-981164

BMS-981164 是一种人源抗 IL31 IgG1-κ 单克隆抗体。BMS-981164 可有效抑制 IL-31 信号通路。BMS-981164 的同型对照可参考 Human IgG1 kappa, Isotype Control (HY-P99001)。BMS-981164 可用于特应性皮炎的相关研究。

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BMS-981164

BMS-981164 Chemical Structure

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BMS-981164 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BMS-981164 is a human anti-IL31 IgG1-κ monoclonal antibody. BMS-981164 effectively inhibits the IL-31 signaling pathway. The isotype control of BMS-981164 can be referenced to Human IgG1 kappa, Isotype Control (HY-P99001). BMS-981164 is applicable to research related to atopic dermatitis[1].

同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

IL-31
体外研究
(In Vitro)

BMS-981164 (0.01-10000 pM；6 h) 在 PathHunter U2OS IL31RA/OSMR 二聚化细胞中以剂量依赖的方式抑制 IL-31 信号通路[1] 。
BMS-981164 (5 nM; 24 h) 可抑制人支气管上皮 BEAS-2B 细胞中 IL-4/IL-31 诱导的 CCL2 分泌[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BMS-981164 相关抗体:

ELISA Assay[1]

Cell Line: human bronchial epithelial BEAS-2B cells
Concentration: 5 nM
Incubation Time: 24 h
Result: Inhibited IL-4/IL-31-induced CCL2 secretion in BEAS-2B cells, with efficacy matched by NM26-2198.
基因 ID

386653  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

146.43 kDa

性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BMS-981164 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-981164BMS981164BMS 981164Interleukin RelatedILatopic dermatitisCCL2IL-31RAIL-31BEAS-2B cellsOSMRβIL-4human bronchial epithelial cellsInhibitorinhibitorinhibit

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产品名称：
BMS-981164
目录号：
HY-P991280
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