2. Cell Cycle/DNA Damage Apoptosis
  3. Eukaryotic Initiation Factor (eIF) CDK c-Myc MDM-2/p53 Caspase Apoptosis
  4. Briciclib sodium

Briciclib (ON 014185) sodium 是一种真核翻译起始因子 4E (eIF4E) 抑制剂。Briciclib sodium 具有广谱抗癌活性，包括套细胞白血病、乳腺癌、胃癌及食管癌细胞。Briciclib sodium 降低了 cyclin D1 和 c-Myc 的表达，增强了 P53 和 Cleaved Caspase 3 促凋亡 (apoptosis) 蛋白的表达。Briciclib sodium 可用于研究造血系统肿瘤和实体瘤。

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Briciclib sodium

Briciclib sodium Chemical Structure

CAS No. : 865784-01-6

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Briciclib sodium 的其他形式现货产品:

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Briciclib sodium 相关抗体

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

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  • 生物活性

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生物活性

Briciclib (ON 014185) sodium is a eukaryotic translation initiation factor 4E (eIF4E) inhibitor. Briciclib sodium exhibits broad-spectrum anti-cancer activity, including in mantle cell leukemia, breast cancer, gastric cancer, and esophageal cancer cells. Briciclib sodium reduces the expression of cyclin D1 and c-Myc, and enhances the expression of P53 and Cleaved Caspase 3 pro-apoptotic proteins. Briciclib sodium can be used for the study of hematological system tumors and solid tumors[1].

分子量

518.38

Formula

C19H21Na2O10PS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Briciclib sodium 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Briciclib865784-01-6ON 014185ON014185ON-014185Eukaryotic Initiation Factor (eIF)CDKc-MycMDM-2/p53CaspaseApoptosisCyclin dependent kinaseMyceIF4EON 013100translation initiationcyclin D1apoptosisoral bioavailabilityanticancer activityInhibitorinhibitorinhibit

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