2. Immunology/Inflammation
  3. FLAP
  4. BRP-7

BRP-7 是一种 5-脂氧合酶激活蛋白 (FLAP) 抑制剂，其 IC50 为 0.31 μM。BRP-7 通过靶向 FLAP 抑制 5-脂氧合酶 (5-LOX) 与 FLAP 的共定位，从而阻断花生四烯酸 (AA) 向 5-LOX 的转移，抑制白三烯 (LTs) 的生成 (IC₅₀ = 0.15 μM)。BRP-7 不抑制环氧合酶 (COX-1/COX-2) 或微粒体前列腺素 E₂合成酶-1 (mPGES-1) ，不影响细胞活力或 AA 释放。BRP-7 在大鼠胸膜炎和小鼠腹膜炎模型中具有显著的抗炎效果。BRP-7 可用于研究炎症性疾病。

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BRP-7

BRP-7 Chemical Structure

CAS No. : 612046-20-5

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BRP-7 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BRP-7 is a 5-lipoxygenase activating protein (FLAP) inhibitor with an IC50 of 0.31 μM. BRP-7 inhibits the co-localization of 5-lipoxygenase (5-LOX) and FLAP by targeting FLAP, thereby blocking the transfer of arachidonic acid (AA) to 5-LOX and suppressing the production of leukotrienes (LTs) (IC₅₀ = 0.15 μM). BRP-7 does not inhibit cyclooxygenase (COX-1/COX-2) or microsomal prostaglandin E₂ synthase-1 (mPGES-1), and does not affect cell viability or AA release. BRP-7 exhibits significant anti-inflammatory effects in rat pleurisy and mouse peritonitis models. BRP-7 can be used for the study of inflammatory diseases[1][2].
分子量

402.96

Formula

C26H27ClN2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BRP-7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRP-7612046-20-5BRP7BRP 7FLAP5-lipoxygenase-activating protein5-LO activating protein5-lipoxygenase5-lipoxygenase activating proteinleukotrienebenzimidazoleinflammationInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-118506
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