2. Metabolic Enzyme/Protease Apoptosis
  3. Carbonic Anhydrase Glutathione Peroxidase Ferroptosis
  4. CA IX/GPX4-IN-1

CA IX/GPX4-IN-1 (Compound 22abcb) 是一种双重靶向 CA IX 和 GPX4 活性的抑制剂。CA IX/GPX4-IN-1 能在低氧条件下通过诱导铁死亡有效杀死 SUM159PT (IC50 = 416 nM) 细胞。CA IX/GPX4-IN-1 在 SUM159PT-CAIX-FL 细胞中对 CA IX 的 IC50 = 663 nM。CA IX/GPX4-IN-1 可显著抑制肿瘤生长并且可被铁死亡 (ferroptosis) 抑制剂逆转。CA IX/GPX4-IN-1 可用于乳腺癌等癌症的研究。

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CA IX/GPX4-IN-1

CA IX/GPX4-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

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CA IX/GPX4-IN-1 相关抗体

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查看 Carbonic Anhydrase 亚型特异性产品:

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CA CA I CA Ⅱ CA IX CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CA IX/GPX4-IN-1 (Compound 22abcb) is a dual targeted inhibitor of CA IX and GPX4 activity. CA IX/GPX4-IN-1 can effectively kill SUM159PT cells (IC50 = 416 nM) by inducing iron death under hypoxic conditions. CA IX/GPX4-IN-1 has an IC50 of 663 nM to CA IX in SUM159PT-CAIX-FL cells. CA IX/GPX4-IN-1 can significantly inhibit tumor growth and can be reversed by ferroptosis inhibitors. CA IX/GPX4-IN-1 can be used for research on breast cancer and other cancers[1].

分子量

511.98

Formula

C25H22ClN3O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CA IX/GPX4-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CA IX/GPX4-IN-1Carbonic AnhydraseGlutathione PeroxidaseFerroptosisCarbonate dehydrataseCA IXGPX4ferroptosisSUM159PTcancerInhibitorinhibitorinhibit

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