2. Membrane Transporter/Ion Channel Neuronal Signaling NF-κB Immunology/Inflammation
  3. TRP Channel NF-κB Interleukin Related
  4. Cannabitwinol

Cannabitwinol 是一种选择性热敏 TRP 调节剂 和 NF-κB 抑制剂。Cannabitwinol 可抑制 TNFα 诱导的 NF-κB 驱动转录及 TNFα 诱导的 IL-8 释放，具有抗炎和抗氧化活性。Cannabitwinol 对冷激活 TRP 通道 (激活 TRPA1 (EC50 = 3.0 μM) 并拮抗 TRPM8 ((IC50 = 3.9 μM))) 具有选择性，而对热激活 TRP (如 TRPV1 和 TRPV2) 通道无显著亲和力。Cannabitwinol 可用于皮肤炎症性疾病、冷异常性疼痛、痛觉过敏的相关研究[1][2]。

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Cannabitwinol

Cannabitwinol Chemical Structure

CAS No. : 2699950-81-5

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Cannabitwinol 相关抗体

Top Publications Citing Use of Products

查看 TRP Channel 亚型特异性产品:

查看所有亚型
TRPA1 TRPC3 TRPC4 TRPC5 TRPM8 TRPM2 TRPM3 TRPM4 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cannabitwinol is a selective thermosensitive TRP modulator and NF-κB inhibitor. Cannabitwinol inhibits TNFα-induced NF-κB-driven transcription and TNFα-induced IL-8 release, and exhibits anti-inflammatory and antioxidant activities. Cannabitwinol shows selectivity for cold-activated TRP channels, activating TRPA1 (EC50 = 3.0 μM) and antagonizing TRPM8 (IC50 = 3.9 μM), but has no significant affinity for heat-activated TRP channels such as TRPV1 and TRPV2. Cannabitwinol can be used in research related to inflammatory skin diseases, cold allodynia, and hyperalgesia[1][2].

IC50 & Target[1][2]

NF-κB

 

IL-8

 

TRPA1

3.0 μM (EC50)

TRPM8

3.9 μM (IC50)

体外研究
(In Vitro)

Cannabitwinol (0.5-20 μM；6 h) 可抑制 HaCaT 细胞中 TNFα 诱导的 IL-8 释放 (IC50 = 6.39 μM) 以及 NF-κB 介导的转录 (IC50 = 19.8 μM)，在 20 μM 浓度下观察到显著的 NF-κB 抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cannabitwinol 相关抗体:

ELISA Assay[1]

Cell Line: HaCaT human keratinocytes
Concentration: 0.5, 1, 2.5, 5, 10 and 20 μM
Incubation Time: 6 h (cotreatment with TNFα)
Result: Inhibited TNFα-induced IL-8 release with an IC50 of 6.39 μM in a concentration-dependent manner.
Inhibited TNFα-induced NF-κB-driven transcription with an IC50 of 19.8 μM, with a statistically significant effect observed only at 20 μM.
分子量

640.93

Formula

C43H60O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cannabitwinol 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cannabitwinol2699950-81-5CBDDTRP ChannelNF-κBInterleukin RelatedTransient receptor potential channelsNuclear factor-κBNuclear factor-kappaBILHaCaT cellsHEK-293 cellsIL-8rTRPA1TNFαPOPC membraneTRPA1rTRPM8Nuclear factor-kappa B (NF-κB)TRPM8Inhibitorinhibitorinhibit

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产品名称：
Cannabitwinol
目录号：
HY-179432
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