2. Metabolic Enzyme/Protease Anti-infection
  3. Carbonic Anhydrase Bacterial
  4. Carbonic anhydrase-IN-2

Carbonic anhydrase-IN-2 是一种具有口服活性的碳酸酐酶 (carbonic anhydrase) 抑制剂。Carbonic anhydrase-IN-2 对多种耐万古霉素肠球菌 (VRE) 菌株具有抗菌作用。Carbonic anhydrase-IN-2 可用于感染相关研究，如屎肠球菌 (E. faecium)。

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Carbonic anhydrase-IN-2

Carbonic anhydrase-IN-2 Chemical Structure

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Carbonic anhydrase-IN-2 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Carbonic anhydrase-IN-2 is an orally active carbonic anhydrase inhibitor. Carbonic anhydrase-IN-2 shows antibacterial effect against various vancomycin-resistant Enterococcus (VRE) strains. Carbonic anhydrase-IN-2 can be used for the research of infection, such as E. faecium[1].

体外研究
(In Vitro)

Carbonic anhydrase-IN-2 (Compound 20) (184-3060 nM, 18-20 h) 可抑制多种耐万古霉素肠球菌 (VRE) 菌株的增殖，包括屎肠球菌 (E. faecium) NR-31909 和粪肠球菌 (E. faecalis) NR-31971，其 MIC50 为 184 nM，MIC90 为 3060 nM[1]。
Carbonic anhydrase-IN-2 能强效抑制屎肠球菌 α-碳酸酐酶 (Efα-CA) (Ki 值为 31.6 nM) 和 γ-碳酸酐酶 (Efγ-CA) (Ki 值为 62.3 nM) [1]。
Carbonic anhydrase-IN-2 (24 h) 对屎肠球菌 NR-31909 具有抑菌作用[1]。
Carbonic anhydrase-IN-2 (18-20 h) 对包括乳杆菌、拟杆菌和双歧杆菌在内的 12 种肠道共生菌株无抑制活性， MIC 大于 784 μM[1]。
Carbonic anhydrase-IN-2 (0-128 μg/mL, 24 h) 在非洲绿猴肾细胞中无明显细胞毒性，可维持 95-100% 的细胞活力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Carbonic anhydrase-IN-2 相关抗体:

Cell Viability Assay[1]

Cell Line: Vero cells
Concentration: 0, 4, 8, 16, 32, 64 nd 128 μg/mL
Incubation Time: 24 h
Result: Maintained cell viability at 95-100%.
体内研究
(In Vivo)

Carbonic anhydrase-IN-2 (Compound 20) (20 mg/kg，口服，每天一次，连续 3 天，从感染后 1 小时开始给药) 显著提高了感染屎肠球菌 (i>E. faecium) R-31909 败血症性腹膜炎的 BALB/c 小鼠的存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: E. faecium NR-31909 septicemic peritonitis[1]
Dosage: 20 mg/kg
Administration: Orally administration, daily for 3 days, starting 1 h post-infection
Result: Reduced NR-31909 burden by 96.8% in kidney, 98.7% in liver, and 96.8% in spleen.
分子量

326.39

Formula

C12H14N4O3S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Carbonic anhydrase-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carbonic anhydrase-IN-2Carbonic AnhydraseBacterialCarbonate dehydrataseCarbonic anhydraseVREInfectionE. faeciumE. faecalisInhibitorinhibitorinhibit

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