2. Epigenetics
  3. Histone Methyltransferase
  4. CBX2-IN-1

CBX2-IN-1 是一种 CBX2 抑制剂，其 IC50 为 9.6 μM。CBX2-IN-1 结合 CBX2 的染色质结构域中的 H3K27me3 结合通道，阻断 CBX2 与 H3K27me3 之间的相互作用，并对 CBX2、CBX4、CBX6、CBX7 和 CBX8 表现出选择性亲和力，相较于 CBX1、CBX3 和 CBX5。CBX2-IN-1 可用于前列腺癌的研究 。

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CBX2-IN-1

CBX2-IN-1 Chemical Structure

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CBX2-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CBX2-IN-1 is a CBX2 inhibitor with an IC50 of 9.6 μM. CBX2-IN-1 binds the CBX2 chromodomain’s H3K27me3 binding channel, blocks interaction between CBX2 and H3K27me3, and exhibits selective affinity toward CBX2, CBX4, CBX6, CBX7, and CBX8 over CBX1, CBX3, and CBX5. CBX2-IN-1 can be used for the research of prostate cancers[1].

IC50 & Target[1]

CBX2

9.6 μM (IC50)

体外研究
(In Vitro)

CBX2-IN-1 (compound 37) (50 μM) 在 NanoBRET 实验中抑制 CBX2，其 IC50 为 9.6 μM，可与 CBX2 染色质结构域的芳香笼及 Asp51 残基发生关键相互作用[1]。
CBX2-IN-1 可能因保守的结合相互作用与序列同源性，对 CBX2 及亲缘关系相近的异构体 (CBX4、CBX6、CBX7、CBX8) 表现出比对 CBX1、CBX3 和 CBX5 更高的选择性亲和力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CBX2-IN-1 相关抗体:
分子量

465.54

Formula

C29H27N3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CBX2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CBX2-IN-1Histone MethyltransferasechromodomainCBX2CBX4CBX7CBX6CBX5H3K27me3CBX8CBX1CBX3Inhibitorinhibitorinhibit

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目录号：
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