2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. CCR5 antagonist 4

CCR5 antagonist 4 是一种口服有效的 CCR5 拮抗剂。CCR5 antagonist 4 可用于类风湿性关节炎的研究。

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CCR5 antagonist 4

CCR5 antagonist 4 Chemical Structure

CAS No. : 872879-86-2

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CCR5 antagonist 4 相关抗体

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查看 CCR 亚型特异性产品:

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CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CCR5 antagonist 4 is an orally active CCR5 antagonist. CCR5 antagonist 4 can be studied in research on rheumatoid arthritis[1][2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
0.26 nM
Compound: 7e, AZD-5672
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
[PMID: 22266038]
HEK293 IC50
24 μM
Compound: 7e, AZD-5672
Displacement of 3,7-Bis[2-(4-nitro[3,5-3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane from human ERG expressed in HEK cells after 3 hrs
Displacement of 3,7-Bis[2-(4-nitro[3,5-3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane from human ERG expressed in HEK cells after 3 hrs
[PMID: 22266038]
T-cell IC50
0.69 nM
Compound: 7e, AZD-5672
Antagonist activity at CCR5 in allo T cells assessed as inhibition of MIP-1beta-induced chemotaxis
Antagonist activity at CCR5 in allo T cells assessed as inhibition of MIP-1beta-induced chemotaxis
[PMID: 22266038]
分子量

639.82

Formula

C31H43F2N3O5S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CCR5 antagonist 4 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCR5 antagonist 4872879-86-2CCRCC chemokine receptorInhibitorinhibitorinhibit

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产品名称：
CCR5 antagonist 4
目录号：
HY-139184
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