2. Immunology/Inflammation
  3. CD28
  4. CD28-IN-2

CD28-IN-2 是一种选择性 CD28-B7 相互作用抑制剂 (IC50：22.4 μM)，可直接与 CD28 结合，Kd 值为 24.1 μM。CD28-IN-2 可抑制 CD28 驱动的免疫激活并阻断 T 细胞共刺激。CD28-IN-2 可用于研究抗肿瘤免疫和免疫相关疾病。

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CD28-IN-2

CD28-IN-2 Chemical Structure

CAS No. : 1240857-57-1

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CD28-IN-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CD28-IN-2 is a selective CD28-B7 interaction (IC50: 22.4 μM) inhibitor that binds directly to CD28, with a Kd value of 24.1 μM. CD28-IN-2 inhibits CD28-driven immune activation and blocks T cell costimulation. CD28-IN-2 can be used for the study of antitumor immunity and immune-related disorders[1].

体外研究
(In Vitro)

CD28-IN-2 (5MS-5) (10-50 μM；48 小时) 在由 IFN-γ 预处理的 A549 肿瘤球体和人 PBMC 组成的 3D 共培养模型中，有效抑制 CD28 依赖性细胞因子释放和 T 细胞活化标志物 (IFN-γ、IL-2 和可溶性 CD69 (sCD69))[1]。
在表达 CD28 的 Jurkat T 细胞 (含有 TCR/CD3-CD28 反应性荧光素酶报告基因) 与 Raji 抗原呈递细胞共培养时，CD28-IN-2 表现出剂量依赖性的 CD28 介导的发光抑制作用，IC50 为 10.3 μM[1]。
CD28-IN-2 对 hERG 钾通道的抑制作用较弱 (IC50 > 50 μM)。在 10 μM 浓度下，CD28-IN-2 对主要细胞色素 P450 同工酶的抑制作用也极弱[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CD28-IN-2 相关抗体:

ELISA Assay[1]

Cell Line: A 3D coculture model comprising IFN-γ-primed A549 tumor spheroids and human PBMCs.
Concentration: 10 μM, 25 μM, 50 μM
Incubation Time: 48 h
Result: Resulted in concentration-dependent suppression of Tcell activation, indicating effective inhibition of CD28-mediated costimulation. 
分子量

340.35

Formula

C19H17FN2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CD28-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CD28-IN-21240857-57-1CD28CD28-driven immune activationCD28-B7 interactionssmall molecule CD28 antagonistsInhibitorinhibitorinhibit

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目录号：
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