2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. CDK2-IN-50

CDK2-IN-50 是一种 CDK2 抑制剂 (IC50 = 0.77 nM) 。CDK2-IN-50 可诱导细胞发生 G1 期阻滞，表明其具有有效的 CDK2/细胞周期蛋白 E 靶向机制。CDK2-IN-50 还具有显著的促凋亡 (pro-apoptotic) 作用。CDK2-IN-50 可用于乳腺癌的研究。

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CDK2-IN-50

CDK2-IN-50 Chemical Structure

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Customer Review

CDK2-IN-50 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK2-IN-50 is a CDK2 inhibitor (IC50 = 0.77 nM). CDK2-IN-50 can induce G1 phase arrest, indicating that it has an effective CDK2/cyclin E targeting mechanism. CDK2-IN-50 also has a significant pro-apoptotic effect. CDK2-IN-50 can be used for the study of breast cancer[1].

IC50 & Target[1]

CDK2/cyclinE

0.77 nM (IC50)

体外研究
(In Vitro)

CDK2-IN-50 (Compound 8b) (10 μM) 表现出显著的生长抑制活性，平均 GI% 为 90.51%[1]。
CDK2-IN-50 (0.01-100 μM) 的 GI50 值低至 0.33 μM (针对乳腺癌细胞系)，整个培养板的平均 GI50 值为 5.58 μM[1]。
CDK2-IN-50 (0.33 μM，24 小时) 可导致细胞周期阻滞于 G1 期，MDA-MB-468 细胞中 77.92% 的细胞处于 G1 期[1]。
CDK2-IN-50 (0.33 μM) 可诱导 MDA-MB-468 细胞发生早期凋亡 (15.21%) 、晚期凋亡 (5.87%) ，总凋亡率为 21.08%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK2-IN-50 相关抗体:

Cell Cycle Analysis[1]

Cell Line: MDA-MB-468 cells
Concentration: 0.33 μM
Incubation Time: 24 h
Result: Caused cell cycle arrest in the G1 phase, with 77.92% of cells in the G1 phase.
分子量

457.59

Formula

C27H27N3O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK2-IN-50 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK2-IN-50CDKApoptosisCyclin dependent kinaseCDK2CDK2/cyclin E1MDA-MB-468NCI-H522Breast cancerLeukemiaInhibitorinhibitorinhibit

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目录号：
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