2. Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. CDK Discoidin Domain Receptor Apoptosis Reactive Oxygen Species (ROS) DNA/RNA Synthesis
  4. CDK4/6/BRD4-IN-2

CDK4/6/BRD4-IN-2 (Compound PJ2) 是一种 CDK4/6 和 BRD4 的双重抑制剂，其对 CDK4、CDK6、BRD4 (BD1) 和 BRD4 (BD2) 的 IC50 为 168.75、292.45、23.17 和 3.12 nM。CDK4/6/BRD4-IN-2 对非小细胞肺癌 (NSCLC) 细胞株有强抑制作用。CDK4/6/BRD4-IN-2 通过 ROS 介导的 DNA 损伤诱导细胞周期停滞、衰老和凋亡 (apoptosis)。CDK4/6/BRD4-IN-2 还能有效抑制 NCI-H358 细胞的迁移和侵袭。CDK4/6-IN-2 可用于研究 KRAS 突变的 NSCLC。

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CDK4/6/BRD4-IN-2

CDK4/6/BRD4-IN-2 Chemical Structure

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CDK4/6/BRD4-IN-2 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

查看 Discoidin Domain Receptor 亚型特异性产品:

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DDR1 DDR2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK4/6/BRD4-IN-2 (Compound PJ2) is a dual inhibitor of CDK4/6 and BRD4 with IC50 values for CDK4, CDK6, BRD4 (BD1), and BRD4 (BD2) of 168.75, 292.45, 23.17, and 3.12 nM respectively. CDK4/6/BRD4-IN-2 has a strong inhibitory effect on non-small cell lung cancer (NSCLC) cell lines. CDK4/6/BRD4-IN-2 induces cell cycle arrest, senescence and apoptosis through ROS-mediated DNA damage. CDK4/6/BRD4-IN-2 can also effectively inhibit the migration and invasion of NCI-H358 cells. CDK4/6-IN-2 can be used for the study of KRAS-mutated NSCLC[1].

分子量

873.47

Formula

C45H49ClN12O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK4/6/BRD4-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK4/6/BRD4-IN-2CDKDiscoidin Domain ReceptorApoptosisReactive Oxygen Species (ROS)DNA/RNA SynthesisCyclin dependent kinaseCDK4/6BRD4KRAS-Mutant NSCLCSenescenceAntitumorDual inhibitorsPJ2Drug resistanceInhibitorinhibitorinhibit

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产品名称：
CDK4/6/BRD4-IN-2
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