2. Immunology/Inflammation
  3. Cyclic GMP-AMP Synthase
  4. cGAS-IN-8

cGAS-IN-8 是一种吲唑环状 GMP-AMP 合成酶 (cGAS) 抑制剂，对人 cGAS 的 IC50 为 6 nM。cGAS-IN-8 抑制 THP-1 细胞中 cGAMP 的生成，IC50 为 0.12 µM。cGAS-IN-8 不抑制 hERG 活性。cGAS-IN-8 可用于自身免疫性疾病的研宄。

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cGAS-IN-8

cGAS-IN-8 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

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cGAS-IN-8 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

cGAS-IN-8 is an indazole cyclic GMP-AMP synthase (cGAS) inhibitor with an IC50 of 6 nM for human cGAS. cGAS-IN-8 inhibits cGAMP production in THP-1 cells with an IC50 of 0.12 µM. cGAS-IN-8 does not inhibits hERG activity. cGAS-IN-8 can be used for the research of autoimmune diseases[1].

体外研究
(In Vitro)

cGAS-IN-8 (compound 26) 具有良好的 hERG 活性，不抑制 CYP3A4，且在人肝细胞中未观察到 GSH 加合物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

cGAS-IN-8 相关抗体:
体内研究
(In Vivo)

cGAS-IN-8 (compound 26) (0.5 mg/kg, 5 mg/kg，静脉注射和口服) 在小鼠中表现出良好的药代动力学和安全性特征，具有较高的口服生物利用度，在 C57Bl/6 雌性小鼠中未表现出显著毒性，且具有药代动力学和安全性评估[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

479.81

Formula

C18H18ClF4N5O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

cGAS-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cGAS-IN-8Cyclic GMP-AMP SynthasecGASautoimmune diseasesinflammationhERGInhibitorinhibitorinhibit

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