2. Immunology/Inflammation
  3. COX Interleukin Related NO Synthase
  4. CHNQD-03005

CHNQD-03005 是一种口服有效的抗炎剂。CHNQD-03005 可抑制 iNOS 和 COX-2 的表达，减少炎症信号传导，抑制 NO 生成，并下调促炎细胞因子 TNF-α、IL-6 和 IL-1β。CHNQD-03005 可用于结肠炎等炎症性疾病的研究。

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CHNQD-03005

CHNQD-03005 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

CHNQD-03005 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

查看 NO Synthase 亚型特异性产品:

查看所有亚型
nNOS iNOS eNOS

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CHNQD-03005 is an orally active anti-inflammatory agent. CHNQD-03005 inhibits the expression of iNOS and COX-2, reduces inflammatory signal transduction, suppresses NO production, and downregulates the pro-inflammatory cytokines TNF-α, IL-6 and IL-1β. CHNQD-03005 can be used in the research of inflammatory diseases such as colitis[1].

IC50 & Target[1]

IL-6

 

COX-2

 

IL-1β

 

体外研究
(In Vitro)

CHNQD-03005 (Compound C13) (24 h) 可抑制 LPS (HY-D1056) 刺激的 RAW264.7 细胞中 TNF-α、IL-1β、IL-6 和 NO 的产生，其 IC50 值分别为 0.45 μM、0.086 μM 和 0.095 μM、和 0.038 μM[1]。
CHNQD-03005 (0.2-6 μM) 可抑制 LPS (HY-D1056) 刺激的 RAW264.7 细胞中 iNOS、COX-2 和 IL-1β 的蛋白表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CHNQD-03005 相关抗体:

Western Blot Analysis[1]

Cell Line: LPS (HY-D1056)-stimulated RAW264.7 cells
Concentration: 0.2, 2 and
Incubation Time: 6 μM
Result: Inhibited the protein expression of iNOS, COX-2, and IL-1β in a concentration-dependent manner.
体内研究
(In Vivo)

CHNQD-03005 (1 mg/kg；口服；7-9 天) 可有效改善 DSS (HY-116282C) 诱导小鼠的溃疡性结肠炎症状[1]。
CHNQD-03005 (100 mg/kg；口服；单次给药) 具有良好的安全性，在雄性 C57BL/6J 小鼠中的经口给药 MTD 超过 100 mg/kg[1]。
CHNQD-03005 (20 mg/kg；口服；21 天) 在 ICR 小鼠中耐受性良好[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (male, 8 weeks old) treated DSS (HY-116282C)[1]
Dosage: 1 mg/kg
Administration: p.o.; daily; 7-9 days
Result: Significantly improved body weight loss, DAI scores, and colon length.
Preserved intestinal mucosal integrity, reduced crypt loss and inflammatory infiltration, and restored colonic architecture.
Reduced colon levels of TNF-α and IL-1β to control levels.
分子量

512.55

Formula

C31H28O7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CHNQD-03005 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHNQD-03005CHNQD03005CHNQD 03005COXInterleukin RelatedNO SynthaseCyclooxygenaseILNitric oxide synthasesNOSulcerative colitisRAW264.7 cellsInhibitorinhibitorinhibit

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产品名称：
CHNQD-03005
目录号：
HY-181081
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