2. Apoptosis
  3. Apoptosis
  4. ChoKα inhibitor-3

ChoKα inhibitor-3 是一种含硫的胆碱激酶抑制剂。ChoKα inhibitor-3 可抑制 HChoK α1，IC50 值为 0.66 μM。ChoKα inhibitor-3 也可诱导凋亡。ChoKα inhibitor-3 可用于癌症的研究。

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ChoKα inhibitor-3

ChoKα inhibitor-3 Chemical Structure

CAS No. : 2883822-56-6

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ChoKα inhibitor-3 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ChoKα inhibitor-3 is a sulphur-containing choline kinase inhibitor. ChoKα inhibitor-3 can inhibit HChoK α1 with an IC50 value of 0.66 μM. ChoKα inhibitor-3 also can induce apoptosis. ChoKα inhibitor-3 can be used for the research of cancer[1].

IC50 & Target

IC50: 0.66 μM (HChoK α1); 0.53 μM (A549); 0.26 μM (HeLa); 3.0 μM (HT-29); 1.34 μM (MCF7)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 GI50
0.53 μM
Compound: PL 48
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs
[PMID: 36493617]
Astrocyte GI50
5 μM
Compound: PL 48
Antiproliferative activity against human Astrocyte cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
Antiproliferative activity against human Astrocyte cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
[PMID: 36493617]
HT-29 GI50
3 μM
Compound: PL 48
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs
[PMID: 36493617]
HeLa GI50
0.26 μM
Compound: PL 48
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs
[PMID: 36493617]
MCF-10A GI50
2.6 μM
Compound: PL 48
Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin dye based assay
[PMID: 36493617]
MCF7 GI50
1.34 μM
Compound: PL 48
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs
[PMID: 36493617]
体外研究
(In Vitro)

ChoKα inhibitor-3 (PL 48) has HChoK α1 inhibition activity with an IC50 value of 0.66 μM[1].
ChoKα inhibitor-3 (1.46 μM; 72 h) can inhibit cell proliferation for A549, HeLa, HT-29 and MCF7 cells with IC50 values of 0.53 μM, 0.26 μM, 3.0 μM and1.34 μM, respectively[1].
ChoKα inhibitor-3 (1, 5 μM; 48, 72 h) induces apoptosis in cancer cells through the mitochondrial pathway[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ChoKα inhibitor-3 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HT29, A549, HeLa, HT-29 and MCF7 cells
Concentration: 1.46 μM
Incubation Time: 72 h
Result: Had excellent growth inhibitory property.

Apoptosis Analysis[1]

Cell Line: A549 and HeLa cells
Concentration: 1, 5 μM
Incubation Time: 48, 72 h
Result: Induced a stronger mitochondrial depolarization in HeLa cells at early time-point treatment (24 h).

Western Blot Analysis[1]

Cell Line: HeLa and NHA cells
Concentration: 5 μM
Incubation Time: 48 h
Result: Significantly reduced the expression of the anti-apoptotic protein MCL-1.
分子量

897.65

Formula

C42H42Br2Cl2N4S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ChoKα inhibitor-3 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ChoKα inhibitor-32883822-56-6ChoKα inhibitor3ChoKα inhibitor 3Apoptosischoline kinaseHChoK α1cancerdithioethaneInhibitorinhibitorinhibit

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