Chuanbeinone  (Synonyms: 22-Epidelavinone)

Chuanbeinone (22-Epidelavinone) is an orally active alkaloid found in Fritillaria pallidiflora. Chuanbeinone shows cytotoxicity against mutiple cancer cells and can induces apoptosis and S phase arrest. Chuanbeinone downregulates Bcl-2, upregulates Bax, and activates caspase-3. Chuanbeinone exerts anti-inflammatory and antitussive effects by reducing pro-inflammatory cytokine (IL-1β, IL-6 and TNF-α) production and mRNA expression, and inhibiting TRIF-, MyD88-, NF-κB-, and MAPK-dependent signaling pathways. Chuanbeinone inhibits AChE and BChE with IC₅₀ values of 7.7 and 0.7 μM. Chuanbeinone can be used for the researches of lung carcinoma, cough, inflammatory diseases^[1][2][3][4].

Chuanbeinone 可抑制 LLC、A2780、HepG2 和 A549 细胞的增殖，其对应的 IC₅₀ 值分别为 10.51 μg/mL、18.16 μg/mL、37.97 μg/mL 和 43.74 μg/mL^[1]。
Chuanbeinone (5-15 μg/mL；48 h) 可在 LLC 细胞中诱导剂量依赖性细胞凋亡，细胞凋亡率为 12.8% 至 64.8%^[1]。
Chuanbeinone (10 μg/mL；24-72 h) 可在 LLC 细胞中诱导时间依赖性的 S 期阻滞，G0/G1 期的细胞数量减少^[1]。
Chuanbeinone (5-15 μg/mL；48 h) 可下调 LLC 细胞中的 Bcl-2、上调 Bax 并激活 caspase-3^[1]。
Chuanbeinone (20-100 μM；24 h) 降低 RAW 264.7 细胞活力^[2]。
Chuanbeinone (5-20 μM；与 0.2 μg/mL LPS 共处理 24 h) 可通过减少促炎细胞因子的产生与 mRNA 表达，以及抑制 TRIF-、MyD88-、NF-κB-和 MAPK 依赖的信号通路，对 LPS (HY-D1056) 诱导的 RAW 264.7 细胞发挥抗炎作用^[2]。
Chuanbeinone 对 AChE 的抑制作用 IC₅₀ 为 7.7 ± 0.001 μM，对 BChE 的抑制作用 IC₅₀ 为 0.7 ± 0.001 μM，且在 100 μM 浓度下表现出 70.7 ± 3.3%的酶抑制率^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Chuanbeinone (10-40 mg/kg；口服；每日一次；连续 10 天) 在荷 LLC 的 C57BL/6J 小鼠和荷 S180 的 ICR 小鼠中展现出显著的抗肿瘤活性，诱导肿瘤生长抑制、细胞凋亡以及血管生成抑制^[1]。
Chuanbeinone (1.5-3.0 mg/kg; 口服.; single dose) 在小鼠氨气诱导咳嗽模型中呈现出剂量依赖性的镇咳作用，其中 3.0 mg/kg 剂量可使咳嗽频率被抑制 60.49%^[4]。
Chuanbeinone (3.0 mg/kg；口服；单次给药) 在小鼠气管酚红分泌模型中未表现出显著的祛痰活性^[4]。
Chuanbeinone (1.5-3.0 mg/kg; 口服; single dose) 在二甲苯诱导的小鼠耳肿胀模型中，3.0 mg/kg 剂量时可发挥抗炎作用，肿胀抑制率达 37.08%^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

413.64

C₂₇H₄₃NO₂

103530-47-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang D, et al. Characterization of the Isosteroidal Alkaloid Chuanbeinone from Bulbus of Fritillaria pallidiflora as Novel Antitumor Agent In Vitro and In Vivo. Planta Med. 2016;82(3):195-204.  [Content Brief]

  [2]. Aga EB, et al. Four Isosteroidal Alkaloids from Fritillaria Alleviate Lipopolysaccharide-Induced Inflammation in vitro and in vivo through MyD88- and TRIF-Dependent Signaling Pathways. Chin J Integr Med. 2026 Jan;32(1):54-63.  [Content Brief]

  [3]. Lin BQ, et al. Inhibitors of acetylcholine esterase in vitro--screening of steroidal alkaloids from Fritillaria species. Planta Med. 2006 Jul;72(9):814-8.  [Content Brief]

  [4]. Wang D, et al. Antitussive, expectorant and anti-inflammatory alkaloids from Bulbus Fritillariae Cirrhosae. Fitoterapia. 2011;82(8):1290-1294.  [Content Brief]