1. Anti-infection
  2. SARS-CoV
  3. Cilgavimab

Cilgavimab  (Synonyms: 西加韦单抗; AZD-1061; COV2-2130)

目录号: HY-P99604 纯度: 95.00%
COA 技术支持

Cilgavimab (AZD-1061; COV2-2130) 是一种人源靶向 SARS-CoV-2 的单克隆抗体,可与 Tixagevimab (HY-P99556) 组成单克隆抗体组合 AZD7442。Cilgavimab 对 SARS-CoV-2 感染小鼠模型有保护作用。

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CAS No. : 2420563-99-9

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规格 价格 是否有货 数量
1 mg ¥3000
In-stock
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cilgavimab (AZD-1061; COV2-2130) is a human SARS-CoV-2-neutralizing monoclonal antibody, can compose monoclonal-antibody combination AZD7442 with Tixagevimab (HY-P99556). Cilgavimab shows protective action on mouse models of SARS-CoV-2 infection[1].

同型

Human IgG1 kappa

推荐同型对照抗体
反应种属

Virus

IC50 & Target

Severe acute respiratory syndrome coronavirus 2

体外研究
(In Vitro)

Cilgavimab 和 Tixagevimab 能够同时结合到 SARS-CoV-2 刺突蛋白 (S) 受体结合域的不同、不重叠的表位,以有效中和病毒[1]
Cilgavimab 具有较强的单克隆抗体中和活性和人 ACE2 阻断活性,IC50 为 10-150 ng/mL,并能与三聚体 S2Pecto 蛋白或单体 SRBD 蛋白结合,IC50 为 0.1-10 ng/mL[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Cilgavimab (200 μg/小鼠; 腹腔注射; 感染 SARS-CoV-2 前 1 h 处理) 保护小鼠免于体重减轻,减少病毒负担和肺部炎症水平[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Accession
应用

ELISA, FACS, Functional assay

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

分子量

148.82 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

西加韦单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Cilgavimab
目录号:
HY-P99604
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