2. Metabolic Enzyme/Protease
  3. MetAP
  4. CKD-731

CKD-731 是 Fumagillin (HY-B0751) 的类似物。CKD-731 抑制小牛肺动脉内皮细胞、淋巴瘤 EL-4 细胞和小鼠白血病 P388D1 细胞的增殖。CKD-731 通过抑制 MetAP-2 活性并阻断血管生成发挥作用。CKD-731 可用于抗血管生成相关癌症的研究。

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CKD-731

CKD-731 Chemical Structure

CAS No. : 251111-15-6

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CKD-731 相关抗体

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MetAP2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CKD-731 is a Fumagillin (HY-B0751) analogue. CKD-731 inhibits the proliferation of calf pulmonary artery endothelial cells (CPAE), lymphoma EL-4 cells and murine leukemia P388D1 cells. CKD-731 exerts the effect of inhibiting MetAP-2 activity and blocking angiogenesis. CKD-731 can be used for the research of anti-angiogenesis-related cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CPAE IC50
0.03 μg/mL
Compound: S10
Cytotoxic activity against cow CPAE cells by MTT assay
Cytotoxic activity against cow CPAE cells by MTT assay
[PMID: 31009908]
CPAE IC50
0.00003 ng/mL
Compound: 3d
Tested in vitro for its ability to inhibit cell proliferation of calf pulmonary artery endothelial cells measured calorimetrically by SRB method
Tested in vitro for its ability to inhibit cell proliferation of calf pulmonary artery endothelial cells measured calorimetrically by SRB method
[PMID: 10636239]
EL4 IC50
0.00015 ng/mL
Compound: 3d
Tested in vitro for its ability to inhibit cell proliferation of lymphoma EL-4 cells measured calorimetrically by MTT method
Tested in vitro for its ability to inhibit cell proliferation of lymphoma EL-4 cells measured calorimetrically by MTT method
[PMID: 10636239]
EL4 IC50
0.15 μg/mL
Compound: S10
Antitumor activity against mouse EL4 cells by MTT assay
Antitumor activity against mouse EL4 cells by MTT assay
[PMID: 31009908]
P388 IC50
> 1 ng/mL
Compound: 3d
Tested in vitro for its ability to inhibit cell proliferation of murine leukemia P388D1 cells measured calorimetrically by MTT method
Tested in vitro for its ability to inhibit cell proliferation of murine leukemia P388D1 cells measured calorimetrically by MTT method
[PMID: 10636239]
分子量

502.60

Formula

C28H38O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CKD-731 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CKD-731251111-15-6CKD731CKD 731MetAPMethionine Aminopeptidasecalf pulmonary artery endothelial cells (CPAE)lymphoma EL-4 cellsmurine leukemia P388D1 cellscancerInhibitorinhibitorinhibit

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目录号：
HY-103653
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