2. Metabolic Enzyme/Protease
  3. Acyltransferase
  4. CL 277082

CL 277082 是一种高效且选择性的微粒体酰基辅酶A：胆固醇酰基转移酶 (ACAT) 抑制剂。CL 277082 对肠黏膜微粒体、肝脏和大鼠肾上腺的 ACAT 抑制 IC50 值分别为 0.14 μM、0.74 μM 和 1.18 μM。CL 277082 是一种 ACAT 催化的胆固醇酯化和胆固醇吸收抑制剂。

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CL 277082

CL 277082 Chemical Structure

CAS No. : 96224-26-9

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CL 277082 相关抗体

Top Publications Citing Use of Products

查看 Acyltransferase 亚型特异性产品:

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ACAT1 ACAT2 MGAT2 ACAT DGAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CL 277082 is a potent and selective acyl CoA:cholesterol acyltransferase (ACAT) inhibitor in microsomes. CL 277082 inhibits ACAT with IC50 values of 0.14 μM for intestinal mucosal microsomes, 0.74 μM for liver, and 1.18 μM for rat adrenal. CL 277082 is a ACAT-catalyzed cholesterol esterification and cholesterol absorption inhibitor[1].

体外研究
(In Vitro)

CL 277082 可抑制培养的平滑肌细胞中的 ACAT 活性 (IC50 = 0.8 μM)。CL 277082 不抑制脂肪酸掺入甘油三酯或磷脂。CL 277082 也不抑制其他胆固醇酯化酶，例如卵磷脂胆固醇酰基转移酶 (LCAT) 和胰胆固醇酯酶[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CL 277082 相关抗体:
体内研究
(In Vivo)

CL 277082 是一种强效的胆固醇吸收抑制剂，它能显著抑制喂食胆固醇的大鼠肝脏和血清胆固醇浓度的增加 (ED50 = 5.2 mg/kg/天)，同时增加粪便中中性 14C 标记甾醇的排泄[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

430.57

Formula

C26H36F2N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CL 277082 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CL 27708296224-26-9CL277082CL-277082AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseACAT inhibitorcholesterol esterificationcholesterol absorption inhibitorInhibitorinhibitorinhibit

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产品名称：
CL 277082
目录号：
HY-129344
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