2. NF-κB Stem Cell/Wnt MAPK/ERK Pathway Immunology/Inflammation
  3. NF-κB ERK JNK p38 MAPK Interleukin Related
  4. CLP-d2

CLP-d2 是一种多靶点抗炎剂、破骨细胞生成抑制剂及免疫调节剂，具有优于 Daptomycin (HY-B0108) 的药代动力学特征，以及良好的安全性。CLP-d2 通过降低 c-Fos、NFATc1 的表达水平，减少 IκBα、p65、ERK 及 JNK 的磷酸化水平，抑制 NF-κB 和 MAPK 信号通路，进而减少 IL-6、TNF-α、IL-1β 等促炎细胞因子的分泌，发挥抗炎活性。CLP-d2 抑制小鼠关节内破骨细胞生成，减轻骨侵蚀与关节肿胀，减少滑膜增生和炎症细胞浸润，降低血清类风湿因子 (RF) 水平。CLP-d2 可用于类风湿关节炎的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

CLP-d2

CLP-d2 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

CLP-d2 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 ERK 亚型特异性产品:

查看所有亚型
ERK ERK1 ERK2 ERK5 ERK8

查看 JNK 亚型特异性产品:

查看所有亚型
JNK1 JNK2 JNK3 JNK

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CLP-d2 is a multi-target anti-inflammatory agent, osteoclastogenesis inhibitor and immunomodulator with superior pharmacokinetic properties to Daptomycin (HY-B0108) and good safety profiles. CLP-d2 inhibits the NF-κB and MAPK signaling pathways by reducing the expression levels of c-Fos and NFATc1, and decreasing the phosphorylation levels of IκBα, p65, ERK and JNK, thereby reducing the secretion of pro-inflammatory cytokines such as IL-6, TNF-α and IL-1β to exert anti-inflammatory activity. CLP-d2 inhibits intra-articular osteoclastogenesis in mice, alleviates bone erosion and joint swelling, reduces synovial hyperplasia and inflammatory cell infiltration, and decreases serum rheumatoid factor (RF) levels. CLP-d2 is applicable to related research on rheumatoid arthritis[1].
IC50 & Target

p65

 

IL-6

 

IL-1β

 

I-kappaBalpha

 

体外研究
(In Vitro)

CLP-d2 (10 μg/mL；24 h) 可强效抑制 LPS 刺激的 RAW264.7 细胞中 IL-6、TNF-α 和 IL-1β 的分泌及基因转录，其中对 IL-6 的抑制作用最强[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CLP-d2 相关抗体:

RT-PCR[1]

Cell Line: RAW264.7 cells
Concentration: 10 μg/mL
Incubation Time: 24 h
Result: Inhibits secretion and gene transcription of IL-6, TNF-α, and IL-1β in LPS-stimulated RAW264.7 cells, with the greatest inhibition of IL-6 (93.7% reduction in gene level)
体内研究
(In Vivo)

CLP-d2 (10 mg/kg；i.v.；每 2 天 1 次；持续 40 天) 在胶原诱导性关节炎小鼠中发挥抗类风湿性关节炎作用，可使关节炎评分降低 45.9%，并显著抑制炎症通路与关节破坏[1]。
CLP-d2 (10 mg/kg；i.v.；单剂量) 在 Balb/c 小鼠中表现出良好的药代动力学参数，与达托霉素相比，其 AUC0-t更大、T1/2更长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DBA/1J male mice (6−7 weeks)[1]
Dosage: 10 mg/kg
Administration: i.v.; every 2 days; 40 days
Result: Increased body weight by 12% compared to the CIA group; reduced arthritis score by 45.9% compared to the CIA group; reduced serum RF levels by 46.0%, serum IL-6 levels by 54.2%, serum TNF-α levels by 25.9%, and serum IL-1β levels by 42.6% compared to the CIA group; reduced joint histopathological scores by 70.4% compared to the CIA group; reduced IL-6 IHC scores by 46.4%, IL-1β IHC scores by 59.2%, and TNF-α IHC scores by 49.3% compared to the CIA group; reduced p-IκBα IHC scores by 59.3%, p-p65 IHC scores by 58.6%, p-ERK IHC scores by 60.9%, p-JNK IHC scores by 58.6%, c-Fos IHC scores by 59.1%, and NFATc1 IHC scores by 66.6% compared to the CIA group; reduced bone erosion and paw swelling; inhibited p65 nuclear translocation and osteoclast generation in joints.
Animal Model: Balb/c mice[1]
Dosage: 10 mg/kg
Administration: i.v.; single dose
Result: Reported AUC(0-t) of 255.53 mg/L*h, T1/2 of 1.43 h, Tmax of 0.5 h, VZ of 0.08 L/kg, CLZ of 0.04 L/h/kg, and Cmax of 73.93 mg/L.
分子量

1725.76

Formula

C78H104N18O27
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CLP-d2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CLP-d2NF-κBERKJNKp38 MAPKInterleukin RelatedNuclear factor-κBNuclear factor-kappaBExtracellular signal regulated kinasesc-Jun N-terminal kinaseILosteoclastogenesiscollagen-induced arthritis miceMAPK signaling pathwayrheumatoid arthritisRAW264.7 cellsNF-κB signaling pathwaypro-inflammatory cytokinesNFATc1Balb/c micec-FosInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
CLP-d2
目录号：
HY-P11617
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z