2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. CMF9

CMF9，一种环状肽类分子，是一种 SMAD2-SMAD4 相互作用的抑制剂。CMF9 通过抑制 SMAD2 磷酸化，CMF9 有效阻断了 SMAD2 与 SMAD4 的异源复合物形成。CMF9 对 SMAD3 或 SMAD1/5/8 的磷酸化没有影响。CMF9 下调纤维化标志物 α-SMA 和 COL1A1 的表达。CMF9通过促进病理性细胞外基质 (ECM) 的降解和抑制炎症，在小鼠模型中展现出了强效的抗纤维化作用。CMF9 可用于研究肝纤维化。

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Custom Peptide Synthesis

CMF9

CMF9 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

CMF9 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CMF9, a cyclic peptide molecule, is an inhibitor of the SMAD2-SMAD4 interaction. CMF9 effectively blocks the formation of the heterodimeric complex of SMAD2 and SMAD4 by inhibiting the phosphorylation of SMAD2. CMF9 has no effect on the phosphorylation of SMAD3 or SMAD1/5/8. CMF9 downregulates the expression of fibrotic markers α-SMA and COL1A1. CMF9 exhibits potent anti-fibrotic effects in mouse models by promoting the degradation of pathological extracellular matrix (ECM) and inhibiting inflammation. CMF9 can be used for the study of liver fibrosis[1].
分子量

1163.24

Formula

C53H74N14O16
Sequence

cyclo(Thr-Arg-Pro-Ala-Ser-{d-Phe}-Trp-Glu-Thr-Ser)
Sequence Shortening

cyclo(TRPAS-{d-Phe}-WETS)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CMF9 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CMF9CMF 9CMF-9TGF-beta/SmadTransforming growth factor betaCyclic peptideHepatic fibrosisSMAD2-SMAD4 interaction inhibitorStructure-activity relationshipMetabolic stabilityInhibitorinhibitorinhibit

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