2. Apoptosis
  3. TNF Receptor
  4. CO delivery molecule 1

CO delivery molecule 1 (compound 4) 定位于内质网、线粒体和溶酶体。CO delivery molecule 1 的亚细胞定位导致共诱导毒性效应。通过 TNF-α 抑制测定，CO delivery molecule 1 的抗炎作用在没有共释放的情况下发生在纳摩尔水平，并且随着可见光诱导的共释放而增强。

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CO delivery molecule 1

CO delivery molecule 1 Chemical Structure

CAS No. : 1972616-04-8

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CO delivery molecule 1 相关抗体

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查看 TNF Receptor 亚型特异性产品:

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CO delivery molecule 1 (compound 4) localizes to the endoplasmic reticulum, mitochondria, and lysosomes. Subcellular localization of CO delivery molecule 1 results in CO-induced toxicity effects. Anti-inflammatory effects of CO delivery molecule 1, as measured by TNF-α suppression, occur at the nanomolar level in the absence of CO release, and are enhanced with visible-light-induced CO release[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
10.7 μM
Compound: 4
Cytotoxicity against human A549 cells assessed as inhibition of cell viability preincubated under visible light-induced CO release condition for 1 hr followed by incubation with drug for 23 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as inhibition of cell viability preincubated under visible light-induced CO release condition for 1 hr followed by incubation with drug for 23 hrs by MTT assay
[PMID: 35178180]
A549 IC50
> 100 μM
Compound: 4
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs under dark condition by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs under dark condition by MTT assay
[PMID: 35178180]
RAW264.7 IC50
67.2 μM
Compound: 4
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs under dark condition by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs under dark condition by MTT assay
[PMID: 35178180]
分子量

359.42

Formula

C23H21NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CO delivery molecule 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CO delivery molecule 11972616-04-8CO delivery molecule1CO delivery molecule-1TNF ReceptorTumor Necrosis Factor ReceptorTNFRsubcellular localizationCO-induced toxicityanti-inflammatoryCO releaseInhibitorinhibitorinhibit

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产品名称：
CO delivery molecule 1
目录号：
HY-144368
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