2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. COX Lipoxygenase
  4. COX-2/15-LOX-IN-7

COX-2/15-LOX-IN-7 是一种强效，选择性且有口服活性的 COX-2 和 15-LOX 双重抑制剂，其 IC50 值分别为 0.022 μM 和 1.19 μM。COX-2/15-LOX-IN-7 也能抑制 COX-1，其 IC50 值为 28.081 μM。COX-2/15-LOX-IN-7 对人结直肠癌 HT-29 和 HCT116 细胞系的细胞毒性较低 (IC50 值均大于 100 μM)。COX-2/15-LOX-IN-7 具有非致溃疡特性。COX-2/15-LOX-IN-7 可用于癌症研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

COX-2/15-LOX-IN-7

COX-2/15-LOX-IN-7 Chemical Structure

CAS No. : 1860810-23-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

COX-2/15-LOX-IN-7 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

查看 Lipoxygenase 亚型特异性产品:

查看所有亚型
5-LOX 12-LOX 15-LOX

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

COX-2/15-LOX-IN-7 is a potent, selective and orally active dual inhibitor of COX-2 and 15-LOX with IC50 values of 0.022 and 1.19 μM. COX-2/15-LOX-IN-7 also inhibits COX-1 with an IC50 value of 28.081μM. COX-2/15-LOX-IN-7 has low cytotoxicity against human colorectal cancer HT-29 and HCT116 cell lines (IC50 >100 μM for both). COX-2/15-LOX-IN-7 exhibits non-ulcerogenic performance. COX-2/15-LOX-IN-7 can be used for the research of cancer[1].

IC50 & Target[1]

COX-2

0.022 μM (IC50)

15-LOX

1.19 μM (IC50)

COX-1

28.081 μM (IC50)

体内研究
(In Vivo)

COX-2/15-LOX-IN-7 (Compound 4a) (10 mg/kg，口服，每日一次，连续 3 天) 在大鼠胃溃疡发生潜力实验中表现出非溃疡发生特性，溃疡指数为 0[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

366.38

Formula

C22H17F3N2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

COX-2/15-LOX-IN-7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2/15-LOX-IN-71860810-23-6COXLipoxygenaseCyclooxygenaseLOXCOX-2COX-115-LOXHT-29HCT116ulcerogeniccolorectal cancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
COX-2/15-LOX-IN-7
目录号：
HY-179021
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z