2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis Cell Cycle/DNA Damage
  3. STAT Bcl-2 Family CDK
  4. Crispene E

Crispene E 是一种 STAT3 抑制剂，对 STAT3 二聚化的 IC50 为 10.27 μM。Crispene E 对 STAT3 依赖型 MDA-MB-231 乳腺癌细胞具有特异性细胞毒性。Crispene E 可用于乳腺癌的相关研究。

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Crispene E

Crispene E Chemical Structure

CAS No. : 1666128-87-5

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Crispene E 相关抗体

Top Publications Citing Use of Products

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STAT3 STAT5 STAT6 STAT1

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Crispene E is a STAT3 inhibitor with an IC50 of 10.27 μM against STAT3 dimerization. Crispene E exerts specific cytotoxicity against STAT3-dependent MDA-MB-231 breast cancer cells. Crispene E is applicable to research related to breast cancer[1].

体外研究
(In Vitro)

Crispene E (0-100 μM; 24 h) 可选择性降低 STAT3 依赖型 MDA-MB-231 乳腺癌细胞的活力，24 h 后其 IC50 为 5.35 μM，而对 STAT3 缺失的 A4 细胞活性远较低[1]。
Crispene E (100 μM; 24 h) 可在依赖 STAT3 的 MDA-MB-231 乳腺癌细胞中下调 STAT3 及其靶基因 bcl-2、cyclin D1 和 fascin 的 mRNA 表达[1]。
Crispene E (5 μM; 24 h) 可在血清饥饿、经 IL-6 处理的 MDA-MB-231 乳腺癌细胞中选择性下调 pSTAT3 和 fascin 蛋白水平，而对 pSTAT1 无影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Crispene E 相关抗体:

RT-PCR[1]

Cell Line: STAT3-dependent MDA-MB-231 breast cancer cells
Concentration: 100 μM
Incubation Time: 24 h
Result: Notably downregulated mRNA expression of STAT3.
Notably downregulated mRNA expression of STAT3-dependent target genes including bcl-2, cyclin D1, and fascin.
Caused particularly significant down-regulation of bcl-2.
分子量

346.42

Formula

C20H26O5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Crispene E 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Crispene E1666128-87-5STATBcl-2 FamilyCDKCyclin dependent kinaseA4 cellsbreast cancer cellsMDA-MB-231 breast cancer cellsInhibitorinhibitorinhibit

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