2. GPCR/G Protein Metabolic Enzyme/Protease
  3. Prostaglandin Receptor Lipoxygenase
  4. CV-6504

CV-6504 是一种 TXA2 合成酶和 5-脂氧合酶 (5-lipoxygenase) 的双重抑制剂。CV-6504 能够清除 ROS 并表现出抗肿瘤活性。CV-6504 可用于癌症、炎症和心血管疾病的研究。

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CV-6504

CV-6504 Chemical Structure

CAS No. : 117574-40-0

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CV-6504 相关抗体

Top Publications Citing Use of Products

查看 Prostaglandin Receptor 亚型特异性产品:

查看所有亚型
DP EP FP IP TXA2/TP TXB2

查看 Lipoxygenase 亚型特异性产品:

查看所有亚型
5-LOX 12-LOX 15-LOX

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CV-6504 is a dual inhibitor of TXA2 synthase and 5-lipoxygenase. CV-6504 can scavenge ROS and exhibit antitumor activity. CV-6504 can be used for the researches of cancer, inflammation and cardiovascular disease[1][2].

IC50 & Target[1]

TXA2 synthase

 

5-Lipoxygenase

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MAC13 IC50
6.3 x 10-6 M
Compound: CV-6504
Inhibitory activity against MAC13 cell lines
Inhibitory activity against MAC13 cell lines
[PMID: 12852938]
MAC16 IC50
4.75 x 10-6 M
Compound: CV-6504
Inhibitory activity against MAC16 cell lines
Inhibitory activity against MAC16 cell lines
[PMID: 12852938]
RBL-1 IC50
62 nM
Compound: CV-6504
The compound was tested for inhibitory activity against 5-HETE synthesis in rat RBL-1
The compound was tested for inhibitory activity against 5-HETE synthesis in rat RBL-1
[PMID: 1635053]
RBL-1 IC50
1.8 x 10-6 M
Compound: 24
The concentration required to reduce by 50% the amount of LTB4 formed by RBL-1 cells
The concentration required to reduce by 50% the amount of LTB4 formed by RBL-1 cells
[PMID: 1992126]
分子量

241.29

Formula

C15H15NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CV-6504 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CV-6504117574-40-0CV6504CV 6504Prostaglandin ReceptorLipoxygenaseLOXInhibitorinhibitorinhibit

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目录号：
HY-19064
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