2. PROTAC Vitamin D Related/Nuclear Receptor
  3. PROTACs Estrogen Receptor/ERR
  4. CV2a

CV2a 是一种 14-3-3 导向的分子胶基 PROTAC，它选择性地靶向 ERα 蛋白复合物，EC50 为 0.10 μM。CV2a 协同募集 VHL 到 14-3-3/ERα 复合物，并促进 14-3-3ζ/ERα 复合物的强效多聚泛素化。
(粉色: Ligands for Target Protein for PROTAC 和 ERα 配体 (HY-179597)；蓝色: Ligands for E3 Ligase 和 VHL 配体 (HY-120217)；黑色: 连接子)。

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CV2a

CV2a Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

CV2a 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 Estrogen Receptor/ERR 亚型特异性产品:

查看所有亚型
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CV2a is a 14-3-3-directed molecular glue-based PROTAC that selectively targets the ERα protein complex with an EC50 of 0.10 μM. CV2a cooperatively recruits VHL to the 14-3-3/ERα complex and promotes robust polyubiquitination of the 14-3-3ζ/ERα complex[1]. (Pink: Ligands for Target Protein for PROTAC and ERα ligand (HY-179597); Blue: Ligands for E3 Ligase and VHL ligand (HY-120217); Black: linker).

分子量

1248.65

Formula

C68H105N5O14S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CV2a 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CV2aPROTACsEstrogen Receptor/ERR14-3-3molecular glue-based PROTACInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-179576
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