2. Immunology/Inflammation GPCR/G Protein
  3. COX Prostaglandin Receptor
  4. CXT29

CXT29 是一种口服有效的 COX-2 抑制剂和血栓素 A2 受体 (TP) 拮抗剂。CXT29 具有 COX 抑制活性与选择性，对 COX-2 和 COX-1 的 IC50 分别为 13 和 722 nM。CXT29 抑制 U-46619 (HY-108566) (TP 激动剂) 诱导的血小板聚集，IC50 为 96 nM。CXT29 有效抑制 TXB₂ 和 PGE₂ 生成，显著抑制小鼠血小板聚集和炎症性疼痛。CXT29 可用于研究炎症性疼痛和心血管疾病。

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CXT29

CXT29 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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规格 是否有货
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Customer Review

CXT29 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

查看 Prostaglandin Receptor 亚型特异性产品:

查看所有亚型
DP EP FP IP TXA2/TP TXB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CXT29 is an orally active COX-2 inhibitor and a thromboxane A2 receptor (TP) antagonist. CXT29 exhibits COX inhibitory activity and selectivity, with IC50 values of 13 and 722 nM for COX-2 and COX-1 respectively. CXT29 inhibits platelet aggregation induced by U-46619 (HY-108566) (a TP agonist), with an IC50 of 96 nM. CXT29 effectively inhibits the production of TXB₂ and PGE₂, significantly reducing platelet aggregation and inflammatory pain in mice. CXT29 can be used for research on inflammatory pain and cardiovascular diseases[1].

IC50 & Target[1]

COX-2

13 nM (IC50)

COX-1

722 nM (IC50)

TP

96 nM (IC50)

分子量

367.41

Formula

C22H22FNO3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CXT29 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CXT29CXT 29CXT-29COXProstaglandin ReceptorCyclooxygenaseCyclooxygenase-2 inhibitorsThromboxane receptor antagonistsDual-action anti-inflammatory agentsPyranoindole scaffoldStructure-activity relationshipPlatelet aggregationPharmacokineticsIn vivo efficacyInhibitorinhibitorinhibit

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产品名称：
CXT29
目录号：
HY-179246
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