2. Immunology/Inflammation
  3. Cyclophilin
  4. CypD-IN-6

CypD-IN-6 是一种强效的 Cyclophilin D (CypD/PPIF) 抑制剂，可抑制 CypD 的 PPIase 活性 (Ki = 32 nM)，并与 CypD 结合 (Kd = 60 nM)。CypD-IN-6 可用于与线粒体通透性转换孔 (MPTP) 相关的疾病研究，例如缺血再灌注损伤与急性胰腺炎。

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CypD-IN-6

CypD-IN-6 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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CypD-IN-6 相关抗体

Top Publications Citing Use of Products

查看 Cyclophilin 亚型特异性产品:

查看所有亚型
Cyclophilin A Cyclophilin B Cyclophilin C Cyclophilin D Cyclophilin G Cyclophilin E

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CypD-IN-6 is a potent cyclophilin D (CypD/PPIF) inhibitor that inhibits CypD PPIase activity (Ki = 32 nM) and binds to CypD (Kd = 60 nM). CypD-IN-6 can be used for mitochondrial permeability transition pore (MPTP) related disease research such as ischemia-reperfusion injury and acute pancreatitis1.

IC50 & Target1

Cyclophilin D

32 nM (Ki)

体外研究
(In Vitro)

CypD-IN-6 (10 μM) 可提高分离小鼠肝线粒体的钙潴留能力 (CRC)[1]。
CypD-IN-6 对从 CypD 基因敲除 (Ppif-/-) 小鼠中分离的线粒体无保护作用，这与其作用机制依赖 CypD 相一致[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CypD-IN-6 相关抗体:
分子量

432.31

Formula

C19H22BrN5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CypD-IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CypD-IN-6CyclophilinCypD inhibitorPPIF inhibitorcyclophilin DPPIase inhibitormitochondrial permeability transition pore (mPTP)mitochondrial dysfunctionInhibitorinhibitorinhibit

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产品名称：
CypD-IN-6
目录号：
HY-179416
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