2. Immunology/Inflammation
  3. Cyclophilin
  4. CypD-IN-7

CypD-IN-7 是一种强效的 Cyclophilin D (CypD/PPIF) 抑制剂，可抑制 CypD 的 PPIase 活性 (Ki = 2.4 nM)，具有线粒体通透性转换孔 (MPTP) 开放保护作用。CypD-IN-7 可用于胰腺炎研究。

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CypD-IN-7

CypD-IN-7 Chemical Structure

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CypD-IN-7 相关抗体

Top Publications Citing Use of Products

查看 Cyclophilin 亚型特异性产品:

查看所有亚型
Cyclophilin A Cyclophilin B Cyclophilin C Cyclophilin D Cyclophilin G Cyclophilin E

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CypD-IN-7 is a potent cyclophilin D (CypD/PPIF) inhibitor that inhibits CypD PPIase activity (Ki = 2.4 nM) and provides protection against mitochondrial permeability transition pore (MPTP) opening. CypD-IN-7 can be used for pancreatitis research[1].

IC50 & Target1

Cyclophilin D

2.4 nM (Ki)

体外研究
(In Vitro)

CypD-IN-7 (18f) (39 nM-5 μM) 可在分离小鼠肝线粒体中提高钙潴留能力 (CRC)[1]。
CypD-IN-7 (10 μM) 可显著提高线粒体钙潴留能力 (CRC)，且在 300 nM 条件下较 CsA 表现出显著更强的 MPTP 开放保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CypD-IN-7 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route Indicator value
Mice 20 mg/kg i.p. Tmax 2.00 h
Mice 20 mg/kg i.p. Cmax 1633 ng/mL
Mice 20 mg/kg i.p. T1/2 3.70 h
Mice 20 mg/kg i.p. AUClast 8860 ng·h/mL
Mice 20 mg/kg i.p. AUCinf 8940 ng·h/mL
体内研究
(In Vivo)

CypD-IN-7 (18f) (50 mg/kg; i.p.; 在第 3 次与第 6 次雨蛙素 (HY-A0190) 注射后立即给药，并在第 7 次注射后 2 h 再给药) 可在 CER-AP 小鼠模型中显著降低血清淀粉酶、胰腺 MPO 活性、水肿/炎症评分及总体组织学评分；而 20 mg/kg 无显著效果[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type C57BL6/J male and female mice (10-12 weeks old); CER-AP induced by 7 hourly i.p. injections of caerulein (50 μg/kg)1
Dosage: 20 mg/kg; 50 mg/kg
Administration: i.p.; administered immediately after the 3rd and 6th Caerulein injections and 2 h after the 7th injection (end of the 2nd, 5th, and 8th hour of the experiment).
Result: 50 mg/kg (three doses) significantly reduced CER-elevated serum amylase, pancreatic MPO activity, and overall histology score; trypsin also showed a marked reduction, while 20 mg/kg showed no significant effect.
分子量

755.28

Formula

C41H44ClFN6O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CypD-IN-7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CypD-IN-7CyclophilinCypD inhibitorPPIF inhibitorcyclophilin DPPIase inhibitormitochondrial permeability transition pore (MPTP/mPTP)calcium retention capacity (CRC)Inhibitorinhibitorinhibit

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目录号：
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