2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor α-synuclein Amyloid-β
  4. D-520

D-520 是一种强效且可透过血脑屏障的多巴胺 D2/D3 受体激动剂 (D2 EC50 = 4.73 nM, Ki = 41.8 nM; D3 EC50 = 2.18 nM, Ki = 0.35 nM)。D-520 在体外抑制 Aβ 聚集体的形成，并促进 α- 突触核蛋白 (α-syn) 和 Aβ 聚集体的解聚。D-520 在帕金森病 (PD) 动物模型中显示出功效。D-520 可用于帕金森病 (PD) 和帕金森病伴痴呆 (PDD) 的相关研究[1][2]。

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D-520

D-520 Chemical Structure

CAS No. : 1619269-47-4

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D-520 相关抗体

Top Publications Citing Use of Products

查看 Dopamine Receptor 亚型特异性产品:

查看所有亚型
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

查看 α-synuclein 亚型特异性产品:

查看所有亚型
α-synuclein α-synuclein Aggregation α-synuclein/CHMP2B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

D-520 is a potent and brain-penetrant dopamine D2/D3 agonist (D2 EC50 = 4.73 nM, Ki = 41.8 nM; D3 EC50 = 2.18 nM, Ki = 0.35 nM). D-520 inhibits the formation of Aβ aggregates in vitro and promotes the disaggregation of both alpha-synuclein (α-syn) and Aβ aggregates. D-520 exhibits efficacious activity in animal models of Parkinson’s disease (PD). D-520 can be used for PD and PD with dementia (PDD) research[1][2].

IC50 & Target[2]

D2 Receptor

4.73 nM (EC50)

D3 Receptor

2.18 nM (EC50)

D2L Receptor

41.8 nM (Ki)

D3 Receptor

0.35 nM (Ki)

体外研究
(In Vitro)

D-520 (0.01-30 μM，24 小时) 对 MN9D 多巴胺能细胞中 6- 羟基多巴胺 (6-OHDA) (HY-B1081) 诱导的毒性表现出剂量依赖性的神经保护作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

D-520 相关抗体:
分子量

501.66

Formula

C31H39N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

D-520 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-5201619269-47-4D520D 520Dopamine Receptorα-synucleinAmyloid-βα-Synβ-amyloid peptideAβAbetadopamine D2/D3Aβ aggregatesalpha-synucleinParkinson’s diseasePD with dementiaInhibitorinhibitorinhibit

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