d-KLA Peptide-d₃₀  (Synonyms: D-(KLAKLAK)2-d₃₀)

d-KLA Peptide-d₃₀ (D-(KLAKLAK)2-d₃₀) is the deuterium labeled d-KLA Peptide (HY-P10285). d-KLA Peptide is a synthetic pro-apoptotic peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide activates biochemical pathways associated with apoptosis, including the activation of caspase family proteins and PARP (poly ADP ribose polymerase). d-KLA Peptide can be used to carry and deliver genes or small molecules to enhance anti-tumor effects^[1][2].

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1554.18

C₇₂H₁₀₈D₃₀N₂₀O₁₅

286380-05-0

d-{Lys-{Leu-d10}-Ala-Lys-{Leu-d10}-Ala-Lys-Lys-{Leu-d10}-Ala-Lys-Leu-Ala-Lys}

d-{K-{Leu-d10}-AK-{Leu-d10}-AKK-{Leu-d10}-AKLAK}

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kim H Y, et al. The cell penetrating ability of the proapoptotic peptide, KLAKLAKKLAKLAK fused to the N-terminal protein transduction domain of translationally controlled tumor protein, MIIYRDLISH[J]. Biomaterials, 2011, 32(22): 5262-5268.  [Content Brief]

  [2]. Ko Y T, et al. Cationic liposomes loaded with proapoptotic peptide D-(KLAKLAK) 2 and Bcl-2 antisense oligodeoxynucleotide G3139 for enhanced anticancer therapy[J]. Molecular Pharmaceutics, 2009, 6(3): 971-977.  [Content Brief]