2. Others Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Apoptosis
  3. Drug Intermediate Reactive Oxygen Species (ROS) Apoptosis Keap1-Nrf2 Heme Oxygenase (HO) Bcl-2 Family Caspase
  4. D-Leucine amide-CDDO-Me-HMP

D-Leucine amide-CDDO-Me-HMP 是一种由 CDDO-Me (HY-13324) 和ligustrazine (HY-N0264) 组成的前药。D-Leucine amide-CDDO-Me-HMP 可保护 CCl4 诱导的肝损伤。D-Leucine amide-CDDO-Me-HMP 能够抑制活性氧 (ROS) 的产生，减轻线粒体损伤并抑制细胞凋亡 (apoptosis)。D-Leucine amide-CDDO-Me-HMP 可用于肝脏损伤研究。

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D-Leucine amide-CDDO-Me-HMP

D-Leucine amide-CDDO-Me-HMP Chemical Structure

CAS No. : 2749600-16-4

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D-Leucine amide-CDDO-Me-HMP 相关抗体

Top Publications Citing Use of Products

查看 Heme Oxygenase (HO) 亚型特异性产品:

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HO-1 HO-2

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

D-Leucine amide-CDDO-Me-HMP is a prodrug composed of CDDO-Me (HY-13324) and ligustrazine (HY-N0264). D-Leucine amide-CDDO-Me-HMP can protect against CCl4-induced liver injury. D-Leucine amide-CDDO-Me-HMP can inhibit ROS production, alleviates mitochondrial damage and inhibits cell apoptosis. D-Leucine amide-CDDO-Me-HMP can be used for the research of liver injury[1].

体外研究
(In Vitro)

D-Leucine amide-CDDO-Me-HMP (CHL) (0.05-0.10 μM, 24 h) 在 CCl4 诱导的 LO2 和 RAW264.7 肝损伤细胞模型中显著提高细胞活力[1]。
D-Leucine amide-CDDO-Me-HMP (0.05-0.10 μM, 24 h) 在 CCl4 诱导的 LO2 和 RAW264.7 肝损伤细胞模型中降低 ROS 水平，减轻线粒体损伤并抑制细胞凋亡[1]。
D-Leucine amide-CDDO-Me-HMP (0.05-0.10 μM, 24 h) 在 CCl4 诱导的 LO2 细胞中显著上调 Nrf2 和 HO-1 蛋白的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

D-Leucine amide-CDDO-Me-HMP 相关抗体:

Cell Viability Assay[1]

Cell Line: CCl4 induced LO2 and RAW264.7 liver injury cells
Concentration: 0.05 and 0.10 μM
Incubation Time: 24 h
Result: Showed cell viability of 98.4% in LO2 cells and 92.6% in RAW264.7 cells.

Immunofluorescence[1]

Cell Line: CCl4 induced LO2 and RAW264.7 liver injury cells
Concentration: 0.05 and 0.10 μM
Incubation Time: 24 h
Result: Reduced the fluorescence intensity of DCF.
Reduced the fluorescence intensity of J-monomer and Increased the fluorescence intensity of J-aggregate.
体内研究
(In Vivo)

D-Leucine amide-CDDO-Me-HMP (CHL) (15-30 mg/kg，腹腔注射，在 CCl4 诱导肝损伤后给药) 可改善 CCl4 诱导的 C57BL/6 小鼠肝损伤模型的肝组织形态和病理损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (8 weeks of age, 18–20 g, CCl4-induced liver injury)[1]
Dosage: 15 mg/kg, 30 mg/kg
Administration: Intraperitoneally injection
Result: Reduced serum levels of ALT and AST.
Alleviated steatosis and inflammatory infiltration.
Upregulated the expression of HO-1 (4.2-fold) and NQO1 (5.5-fold) in liver tissue.
Downregulated the expression of p-p65 (5-fold) and pro-apoptotic protein BAX.
Upregulated the expression of anti-apoptotic protein Bcl-2, and inhibited excessive activation of Caspase-3.
分子量

876.18

Formula

C53H73N5O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

D-Leucine amide-CDDO-Me-HMP 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

D-Leucine amide-CDDO-Me-HMP2749600-16-4Drug IntermediateReactive Oxygen Species (ROS)ApoptosisKeap1-Nrf2Heme Oxygenase (HO)Bcl-2 FamilyCaspaseDrug IintermediateHeme OxygenaseLO2RAW264.7Nrf2HO-1Inhibitorinhibitorinhibit

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