2. Apoptosis MAPK/ERK Pathway Immunology/Inflammation
  3. Caspase Apoptosis JNK p38 MAPK Interleukin Related IFNAR
  4. d-T101 peptide

d-T101 peptide 是一种人类激素肽，是一种 T1/ST2 receptor 配体。d-T101 peptide 与 T1/ST2 受体结合并激活 caspases 8、9 和 3 介导的细胞凋亡 (apoptosis)，同时激活 JNKinase 和 p38 MAPKinase。d-T101 peptide 还会改变高尔基体结构，导致功能丧失和内质网 (ER) 应激修复机制下调。d-T101 peptide 具有免疫刺激和抗癌活性，其选择性诱导增殖癌细胞凋亡，增加 IL-2 和 IFN-γ 表达以及 NK 细胞和 M1 巨噬细胞向肿瘤部位的募集。

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Custom Peptide Synthesis

d-T101 peptide

d-T101 peptide Chemical Structure

CAS No. : 2120397-85-3

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d-T101 peptide 相关抗体

Top Publications Citing Use of Products

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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JNK1 JNK2 JNK3 JNK

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

d-T101 peptide, a human hormone-peptide, is a T1/ST2 receptor ligand. d-T101 peptide binds to the T1/ST2 receptor and activates caspases 8, 9 and 3 mediated apoptosis, together with activation of JNKinase and p38 MAPKinase. d-T101 peptide also changes Golgi structural with function loss and downregulation of the endoplasmic reticulum (ER) stress repair mechanism. d-T101 peptide has immunostimulatory and anticancer activity, selectively induces apoptosis in proliferating cancer cells and increases IL-2 and IFN-γ expression as well as the recruitment of NK cells and M1 macrophages to the tumor site[1][2][3].

IC50 & Target[1-3]

Caspase-8

 

Caspase-9

 

Caspase-3

 

IL-2

 

分子量

1897.18

Formula

C96H129N21O20
CAS 号
Sequence

d(Trp-Trp-Thr-Phe-Phe-Leu-Pro-Ser-Thr-Leu-Trp-Glu-Arg-Lys)
Sequence Shortening

d(WWTFFLPSTLWERK)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

d-T101 peptide 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

d-T101 peptide2120397-85-3CaspaseApoptosisJNKp38 MAPKInterleukin RelatedIFNARc-Jun N-terminal kinaseILInterferon-α/β receptorInterferon-alpha/beta receptorHuman hormone-peptideT1/ST2 receptorLigandGolgiEndoplasmic reticulumERImmunostimulatoryAnticancerProliferating cancer cellsNK cellsM1 macrophagesInhibitorinhibitorinhibit

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目录号：
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