2. Metabolic Enzyme/Protease Anti-infection Apoptosis NF-κB Immunology/Inflammation
  3. Endogenous Metabolite Fungal Heme Oxygenase (HO) Apoptosis Reactive Oxygen Species (ROS)
  4. Dankasterone A

Dankasterone A，一种次级代谢产物，可从真菌 (fungus) Talaromyces purpurogenu 中获得。Dankasterone A 上调 HO-1 蛋白表达，诱导凋亡 (Apoptosis) ，并诱导过量 ROS 生成。Dankasterone A 对前列腺癌具有抗肿瘤活性。

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Dankasterone A

Dankasterone A Chemical Structure

CAS No. : 244303-77-3

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Dankasterone A 相关抗体

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HO-1 HO-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dankasterone A is a secondary metabolite. Dankasterone A can be derived from the fungus Talaromyces purpurogenu. Dankasterone A upregulates HO-1 protein expression, induces Apoptosis, induces excessive ROS production. Dankasterone A has anti-cancer activity against prostate cancer[1].

IC50 & Target[1]

Fungal Metabolite

 

HO-1

 

体外研究
(In Vitro)

Dankasterone A (72 h) 可呈剂量依赖性抑制 PC-3 和 22Rv1 前列腺癌细胞的活力，其 IC₅₀ 值分别为 5.10 μM 和 3.41 μM[1]。
Dankasterone A (2.5-10 μM；48 h) 以剂量依赖的方式上调 PC-3 和 22Rv1 前列腺癌细胞中 HO-1 蛋白的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dankasterone A 相关抗体:
分子量

424.62

Formula

C28H40O3
CAS 号
结构分类
初始来源

endolichenic fungus Pleosporales sp.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dankasterone A 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Dankasterone A244303-77-3Endogenous MetaboliteFungalHeme Oxygenase (HO)ApoptosisReactive Oxygen Species (ROS)Heme Oxygenasezebrafish xenograft tumor modelHeme oxygenase-1 (HO-1)apoptosis inducerprostate cancer cellsoxidative stress inducercell proliferation inhibitor22Rv1normal prostate epithelial cellsPC-3reactive oxygen species (ROS)Inhibitorinhibitorinhibit

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