2. Membrane Transporter/Ion Channel
  3. Na+/K+ ATPase
  4. DBM-819

DBM-819 是一种可逆性的 H⁺/K⁺-ATP 酶 (H+/K+-ATPase) 抑制剂，其 IC50 为 5 μM。DBM-819 通过抑制胃粘膜中的质子泵，可逆性阻断胃酸分泌。DBM-819 对 Cysteamine (HY-77591) 诱导的十二指肠溃疡、Indomethacin (HY-14397) 和 Aspirin (HY-14654) 诱导的胃溃疡均表现出显著保护作用，EC50 值分别为 6、3.1 和 4 mg/kg。DBM-819 可用于抗溃疡研究。

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DBM-819

DBM-819 Chemical Structure

CAS No. : 331686-58-9

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DBM-819 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DBM-819 is a reversible inhibitor of H⁺/K⁺-ATPase (H+/K+-ATPase), with an IC50 value of 5 μM. DBM-819 can reversibly block gastric acid secretion by inhibiting the proton pump in the gastric mucosa. It shows significant protective effects against duodenal ulcers induced by Cysteamine (HY-77591), gastric ulcers induced by Indomethacin (HY-14397), and gastric ulcers induced by Aspirin (HY-14654), with EC50 values of 6, 3.1, and 4 mg/kg respectively. DBM-819 can be used in ulcer prevention research[1][2].

分子量

377.48

Formula

C23H27N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DBM-819 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBM-819331686-58-9DBM819DBM 819Na+/K+ ATPaseSodium potassium pumppharmacokineticshepatic first-pass effectsaturable metabolismCYP450 metabolismtissue distributionInhibitorinhibitorinhibit

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目录号：
HY-126751
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