2. Cell Cycle/DNA Damage Apoptosis
  3. Deubiquitinase Apoptosis
  4. DC-U4106

DC-U4106 是一种 USP8 靶向抑制剂，其 Kd 值为 4.7 μM，IC50 值为 1.2 μM。DC-U4106 可作用于泛素化途径，促进 Erα 的降解。DC-U4106 可以抑制剂肿瘤细胞的生长，具有较小毒性，可用于乳腺癌研究。

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DC-U4106

DC-U4106 Chemical Structure

CAS No. : 2410534-62-0

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1 mg ￥3120
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Customer Review

DC-U4106 相关抗体

Top Publications Citing Use of Products

查看 Deubiquitinase 亚型特异性产品:

查看所有亚型
USP1 USP2 USP7 USP8 USP10 USP30 UCHL1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DC-U4106 is a USP8 targeting inhibitor with the Kdvalue of 4.7 μM and the IC50 value of 1.2 μM. DC-U4106 can target the ubiquitin pathway and facilitate the degradation of Erα. DC-U4106 inhibits tumor growth with minimal toxicity and has the potential for the research of breast cancer[1].

IC50 & Target

Kd: 4.7 μM (USP8), IC50: 1.2 μM (USP8)[1].
体外研究
(In Vitro)

DC-U4106 (1.2-45.2 μM) inhibits USP8 and USP2 with the IC50 values of 1.2 μM and 58.4 μM, respectively, and no activity in USP7[1].
DC-U4106 (0-7 μM, 24 hours) reduces mRNA levels of ERα and PR[1].
DC-U4106 (0-5 μM, 24 hours) can regulate the RTK pathway related proteins and the expression of ERα and PR proteins[1].
DC-U4106 (0-5 μM, 12 hours) can induce apoptosis and inhibit cell proliferation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DC-U4106 相关抗体:

Western Blot Analysis[1]

Cell Line: USP8-positive cell line MCF-7
Concentration: 0-5 μM
Incubation Time: 24 hours
Result: Reduced the expression of EGFR, ErbB2, and ErbB3 proteins with increasing concentrations and caused degradation of ERα and PR proteins.

RT-PCR[1]

Cell Line: USP8-positive cell line MCF-7
Concentration: 0-7 μM
Incubation Time: 24 hours
Result: Reduced mRNA levels of ERα and PR.

Cell Proliferation Assay[1]

Cell Line: USP8-positive cell line MCF-7
Concentration: 0-5 μM
Incubation Time:
Result: Inhibited cell growth in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: USP8-positive cell line MCF-7
Concentration: 0-5 μM
Incubation Time: 12 hours
Result: Resulted in increasing in the proportion of apoptotic cells with increasing concentrations.
体内研究
(In Vivo)

DC-U4106 (intraperitoneal injection, 5 mg/kg or 20 mg/kg, every 2 days, 14 days) inhibits the proliferation of tumors and no significantly effects on body weight, organ morphology and structure in BALB/c nude mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice[1]
Dosage: 5 mg/kg , 20 mg/kg
Administration: Intraperitoneal injection, Every 2 days, 14 days
Result: Inhibited tumor growth significantly at a concentration of 20 mg/kg.
分子量

525.56

Formula

C29H27N5O5
CAS 号
性状

固体

颜色

Yellow to brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 25 mg/mL (47.57 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

THF 中的溶解度 : 10 mg/mL (19.03 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9027 mL 9.5137 mL 19.0273 mL
5 mM 0.3805 mL 1.9027 mL 3.8055 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

DC-U4106 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
THF / DMSO 1 mM 1.9027 mL 9.5137 mL 19.0273 mL 47.5683 mL
5 mM 0.3805 mL 1.9027 mL 3.8055 mL 9.5137 mL
10 mM 0.1903 mL 0.9514 mL 1.9027 mL 4.7568 mL
15 mM 0.1268 mL 0.6342 mL 1.2685 mL 3.1712 mL
DMSO 20 mM 0.0951 mL 0.4757 mL 0.9514 mL 2.3784 mL
25 mM 0.0761 mL 0.3805 mL 0.7611 mL 1.9027 mL
30 mM 0.0634 mL 0.3171 mL 0.6342 mL 1.5856 mL
40 mM 0.0476 mL 0.2378 mL 0.4757 mL 1.1892 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DC-U41062410534-62-0DeubiquitinaseApoptosisDUBsUSP8-targeting inhibitorubiquitin pathwayErαbreast cancerInhibitorinhibitorinhibit

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