2. Metabolic Enzyme/Protease Neuronal Signaling NF-κB Immunology/Inflammation
  3. Glycosidase Amyloid-β NF-κB Interleukin Related
  4. DEL-C1

DEL-C1 是一种 CHI3L1 抑制剂。DEL-C1 能够恢复星形胶质细胞清除 Amyloid-β 的能力并修复溶酶体功能。DEL-C1 可以抑制 NF-κB 信号传导和 IL-6 的分泌。DEL-C1 可用于炎症和神经系统疾病的研究，如阿尔茨海默病。

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DEL-C1

DEL-C1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

DEL-C1 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DEL-C1 is a CHI3L1 inhibitor. DEL-C1 can restore the ability to clear Amyloid-β and repair lysosomal function of astrocytes. DEL-C1 can inhibit NF-κB signaling and IL-6 secretion. DEL-C1 can be used for the researches of inflammation and neurological disease, such as Alzheimer's disease[1].

体外研究
(In Vitro)

DEL-C1 (5-25 μM, 30 mins) 可恢复 CHI3L1 诱导的人诱导多能干细胞衍生星形胶质细胞对 Aβ1-42 摄取的减少[1]。
DEL-C1 (5-25 μM, 30 mins) 可改善 CHI3L1 对星形胶质细胞中 DQ-BSA 溶酶体降解的抑制作用[1]。
DEL-C1 (5-25 μM, 30 mins) 可抑制 CHI3L1 驱动的星形胶质细胞中 CHI3L1 和 IL-6 的分泌以及 NF-κB 的激活[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DEL-C1 相关抗体:
分子量

695.87

Formula

C38H45N7O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DEL-C1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DEL-C1GlycosidaseAmyloid-βNF-κBInterleukin Relatedβ-amyloid peptideAβAbetaNuclear factor-κBNuclear factor-kappaBILInhibitorinhibitorinhibit

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目录号：
HY-179214
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