Demoxepam  (Synonyms: 地莫西泮)

Demoxepam is a major metabolite of Chlordiazepoxide. Demoxepam exhibits cytotoxicity activity against cancer cell lines. Demoxepam has anticonvulsant and anxiolytic effects. Demoxepam has an inhibitory effect on in vitro [³H]tryptophan binding to rat hepatic nuclei^[1][2][3].

Demoxepam (230 μM, 2-48 小时) 对 P388 白血病和 B16 黑色素瘤细胞系表现出细胞毒作用^[1]。
Demoxepam (10^-12-10^-4 M, 2 小时) 可抑制 [³H]tryptophan 与大鼠肝细胞核的结合^[3]。
Demoxepam (25 μL, 40 分钟) 对大鼠 GABA_A 苯二氮卓类药物结合位点 (经 ³H- flunitrazepam) 表现出相当的亲和力^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Demoxepam (0-40 mg/kg) 可降低雄性 129Sv/EvTac 小鼠的 SIH 和基础体温^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

286.71

C₁₅H₁₁ClN₂O₂

963-39-3

固体

Light yellow to yellow

地莫西泮

Room temperature in continental US; may vary elsewhere.

• [1]. Moustapha Ouédraogo, et al. In vitro cytotoxicity study of oxaziridines generated after chlordiazepoxide, demoxepam, and desmethylchlordiazepoxide UV irradiation. Drug Chem Toxicol. 2009;32(4):417-23.  [Content Brief]

  [2]. Gregory G Sarris, et al. Demoxepam Derivatization and GC-MS Analysis Produces Erroneous Nordiazepam and Oxazepam Results. J Anal Toxicol. 2019 Jun 1;43(5):406-410.  [Content Brief]

  [3]. Sidransky, H., et al., (1992). Inhibitory effect of demoxepam on tryptophan binding to rat hepatic nuclei. Biochemical medicine and metabolic biology, 47(3), 270–273.  [Content Brief]

  [4]. Vinkers, C. H., et al., (2010). The rapid hydrolysis of chlordiazepoxide to demoxepam may affect the outcome of chronic osmotic minipump studies. Psychopharmacology, 208(4), 555–562.  [Content Brief]