2. 天然产物
  3. 植物 萜类
  4. 兰科 倍半萜
  5. 石斛
  6. Dendronobiloside D

Dendronobiloside D 是一种倍半萜糖苷，可从铁皮石斛中分离得到。Dendronobiloside D 经口服给药后，在大鼠中血脑穿透性较低、吸收迅速，血浆浓度低且清除速度快。大鼠口服铁皮石斛水提物后，Dendronobiloside D 在其心脏、肝脏、脾脏、肺脏、肾脏、胃、大肠、小肠、胸腺及胰腺中广泛分布，但在大鼠脑中几乎检测不到。

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Dendronobiloside D

Dendronobiloside D Chemical Structure

CAS No. : 526222-27-5

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Dendronobiloside D 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dendronobiloside D is a sesquiterpene glycoside that can be isolated from Dendrobium officinale. After oral administration, Dendronobiloside D exhibits low blood-brain penetration, rapid absorption, low plasma concentration and fast clearance in rats. After oral administration of the aqueous extract of Dendrobium officinale to rats, Dendronobiloside D is widely distributed in their heart, liver, spleen, lung, kidney, stomach, large intestine, small intestine, thymus and pancreas, but is almost undetectable in the rat brain[1].

药代动力学
(Parmacokinetics)
Species Dose Route AUC0-t AUC0-∞ Cmax Tmax T1/2 CLz/F Vz/F
Rat[1] 6.25 g/kg p.o. 14.38 ± 1.72 μg/L·h 17.29 ± 1.99 μM/L·h 2.28 ± 0.18 μg/L 1.50 ± 0.55 h 5.72 ± 2.91 h 6.11 ± 0.74 L/h/kg 26.36 ± 32.39 L/kg
体内研究
(In Vivo)

Dendronobiloside D (6.25 g/kg; p.o.; 单剂量) 作为铁皮石斛水提物的组分给予大鼠后，表现出较低的血浆暴露水平，其 Cmax 为 2.28 μg/L，吸收迅速，Tmax 为 1.50 h，终末消除半衰期为 5.72 h[1]。
Dendronobiloside D (6.25 g/kg; i.g.; 单剂量)，作为铁皮石斛水提物的组分给予大鼠后，可广泛分布于内脏和胃肠道组织 (脑除外)，其中在小肠、胃和大肠中的浓度最高[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (male, 6-8 weeks old, 220±20 g)[1]
Dosage: 6.25 g/kg (equivalent raw herb dose, as component of Dendrobium nobile aqueous extract)
Administration: i.g.; single dose
Result: Was detectable in all collected tissues except the brain.
Reached distribution concentration peaks generally within 2 hours post-administration.
Showed declining distribution concentrations between 2 and 6 hours post-administration.
Had tissue distribution levels ranked as: small intestine > stomach > large intestine > pancreas > lungs > kidneys > liver > heart > thymus > spleen > brain (undetectable).
Exhibited concentrations in the gastrointestinal tract (small intestine, stomach, large intestine) approximately 30 times higher than in heart, thymus, and spleen.
分子量

560.63

Formula

C27H44O12
CAS 号
中文名称

金钗石斛苷D
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dendronobiloside D 相关分类

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Keywords:

Dendronobiloside D526222-27-5金钗石斛苷DOthersratsplasmasmall intestineDendrobium nobilebrainheartlungsliverkidneysspleenInhibitorinhibitorinhibit

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