Deoxymikanolide 

Deoxymikanolide is an orally active antibacterial agent that inhibits catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) activities. Deoxymikanolide increases glycan metabolism, phosphorus metabolism, electric conductivity, intrabacterial reactive oxygen species (ROS) levels, and malondialdehyde (MDA) levels, causes cell shrinkage, cytoplasmic damage, and cell disruption in Ralstonia solanacearum. Deoxymikanolide inhibits Acetic acid-induced writhing in mice. Deoxymikanolide can be used for the research of bacterial wilt^[1][2].

Deoxymikanolide (15.625-125 mg/L; 每 2 小时测定一次) 以浓度依赖性方式抑制 Ralstonia solanacearum race #4 小种的生长，在较高浓度下可完全抑制。
Deoxymikanolide (125 mg/L; 2-24 h) 诱导时间依赖性的超微结构损伤，包括细胞萎缩、细胞质泄漏和异常细胞形态，24 h 时出现完全的细胞膜增厚^[1]。
Deoxymikanolide (62.5-125 mg/L; 每 2 小时测定一次，持续 24 小时) 显著提高了 Ralstonia solanacearum race #4 的磷利用比率^[1]。
Deoxymikanolide (62.5-125 mg/L; 每 5 小时测量一次) 抑制了 Ralstonia solanacearum race #4 中 CAT、POD 和 SOD 的活性，其中 SOD 的抑制率在 10 分钟时分别为 73.50% (62.5 mg/L) 和 86.41% (125 mg/L)^[1]。
Deoxymikanolide (62.5-125 mg/L; 24 h) 诱导了 Ralstonia solanacearum race #4 中显著的细胞内 ROS 积累，其水平超过 340 mg/L H₂O₂ 所诱导的水平^[1]。
Deoxymikanolide (62.5-125 mg/L; 24 h post-treatment) 使 Ralstonia solanacearum race #4 在 24 h 时 MDA 水平升高，表明过量 ROS 引起的脂质过氧化。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Deoxymikanolide (10 mg/kg；p.o.) 可抑制雄性瑞士小鼠 Acetic acid (HY-Y0319) 致扭体疼痛模型的扭体反应，抑制率为 67.3%^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

276.28

C₁₅H₁₆O₅

23753-57-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Li Y, et al. Deoxymikanolide adversely altered physiology and ultrastructure of Ralstonia solanacearum. Pestic Biochem Physiol. 2021;174:104803.  [Content Brief]

  [2]. Ahmed M, et al. Analgesic sesquiterpene dilactone from Mikania cordata. Fitoterapia. 2001;72(8):919-921.  [Content Brief]