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  3. Derrisaponin A

Derrisaponin A 是一种可于 Derris eriocarpa How 茎中发现的齐墩果烷型三萜皂苷和甜味剂,在 1% 浓度下其甜度约为 Sucrose (HY-B1779) 的 80 倍。Derrisaponin A 无急性毒性。Derrisaponin A 可用于高血压、高血糖和肥胖症的研究。

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Derrisaponin A

Derrisaponin A Chemical Structure

CAS No. : 1965272-21-2

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Derrisaponin A is an oleanane-type triterpenoid saponin and sweetener found in the stems of Derris eriocarpa, with sweetness intensity approximately 80 times that of Sucrose (HY-B1779) at 1% concentration. Derrisaponin A shows no acute toxic activity. Derrisaponin A can be used for research on hypertension, hyperglycemia, and obesity[1].

体外研究
(In Vitro)

Derrisaponin A (Compound 2) (2 mg;2 小时) 经酸水解可生成 D-glucuronic acid (HY-N6612)、D-galactose (HY-N0210)、L-rhamnose (HY-N1420) 和 D-glucose (HY-B0389)[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Derrisaponin A (Compound 2) (400 mg/kg bw;静脉注射;单次给药) 在 ICR 小鼠中最大耐受剂量为 400 mg/kg bw,14 天内未观察到持续性急性毒性作用[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (male and female, 3-4 weeks old, specific pathogen-free)[1]
Dosage: 400 mg/kg bw
Administration: i.v.; single injection
Result: Observed transient diaphragm spasm in one mouse that resolved within 10 minutes post-injection.
Detected no other treatment-related clinical signs of toxicity, mortality, or gross pathological changes to internal organs over the 14-day observation period.
Determined the maximum tolerated dose (MTD) to be 400 mg/kg bw.
分子量

1177.28

Formula

C56H88O26

CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Derrisaponin A
目录号:
HY-N19794
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