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  4. Dezaguanine

Dezaguanine 是一种嘌呤类似物。Dezaguanine 在白血病和乳腺癌细胞中表现出抗肿瘤活性。Dezaguanine 可用于癌症相关研究。

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Dezaguanine

Dezaguanine Chemical Structure

CAS No. : 41729-52-6

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Dezaguanine 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dezaguanine is a purine analog. Dezaguanine exhibits antitumor activity in leukemia and breast cancer cells. Dezaguanine can be used in cancer-related research[1][2].

体外研究
(In Vitro)

Dezaguanine (0.1-150 μg/mL) 可抑制原代兔肾细胞、Vero 细胞和 HeLa 细胞中病毒诱导的致细胞病变作用，对所有受试病毒的 IC50 范围为 0.1 至 150 μg/mL[1]。
Dezaguanine (0.01-1.50 mM; 7 days) 可抑制野生型 CHO 细胞的生长，APRT 酶缺陷型 CHO AAR-6a 细胞的生长以及 HGPRT 酶缺陷型 CHO TGR-1 细胞的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dezaguanine 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Wild-type CHO cells, APRTase-deficient CHO AAR-6a cells, HGPRTase-deficient CHO TGR-1 cells
Concentration: 0.01 mM; 0.50 mM; 1.50 mM
Incubation Time: 7 days
Result: Inhibited growth with a minimum inhibitory concentration of 0.01 mM in wild-type CHO cells.
Inhibited growth with a minimum inhibitory concentration of 0.50 mM in APRTase-deficient CHO AAR-6a cells.
Inhibited growth with a minimum inhibitory concentration of 1.50 mM in HGPRTase-deficient CHO TGR-1 cells.
体内研究
(In Vivo)

Dezaguanine (静脉注射/腹腔注射；单次/5 天) 在小鼠中表现出单次静脉给药时 LD10 为 98 mg/kg，连续 5 天每日腹腔给药时 LD10 为 112 mg/kg/day[2]。
Dezaguanine (17-270 mg/kg; 静脉注射; 单次/5 天) 在单次静脉注射 270 mg/kg 剂量时仅会在 Beagle 犬中引发轻微胃肠道反应，而连续 5 天静脉注射 17 mg/kg 的剂量则具有致死性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Beagle[2]
Dosage: 270 mg/kg (single i.v. dose); 17 mg/kg/day (5-day daily i.v. dose)
Administration: i.v. (single dose; daily; 5 consecutive days)
Result: Caused only mild emesis and anorexia, with no detectable organ toxicities via biochemical or histological evaluation (single i.v. 270 mg/kg dose).
Was lethal, with death secondary to necrotizing enteritis and myelosuppression (5-day daily i.v. 17 mg/kg dose).
分子量

150.14

Formula

C6H6N4O
CAS 号
中文名称

地扎胍宁
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dezaguanine 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dezaguanine41729-52-6地扎胍宁Drug DerivativeDrug derivativerat liver guanaseHeLa cellsVero cellsCHO cellsbreast cancer cellsprimary rabbit kidney cellsP388 lymphocytic leukemiaInhibitorinhibitorinhibit

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