2. Others Apoptosis Cell Cycle/DNA Damage NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Drug Derivative MDM-2/p53 CDK Reactive Oxygen Species (ROS) Apoptosis Bcl-2 Family Caspase
  4. Dimethyl bisphenolate

Dimethyl bisphenolate (Compound DMB) 是一种具有口服抗肿瘤活性的天然新木脂素衍生物。Dimethyl bisphenolate 能够抑制癌细胞的增殖、侵袭和迁移。Dimethyl bisphenolate 可激活 p53 信号通路，上调 p21 蛋白的表达，抑制 CDK1-cyclin B1 复合物的活性，使细胞停滞在 G2/M 期。Dimethyl bisphenolate 可诱导活性氧 (ROS) 的产生，上调促凋亡蛋白 Noxa 和 Bim，下调抗凋亡蛋白 Bcl-2，激活 caspase-9 和 caspase-3，并最终诱导细胞凋亡 (apoptosis)。Dimethyl bisphenolate 可用于胶质母细胞瘤的研究。

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Dimethyl bisphenolate

Dimethyl bisphenolate Chemical Structure

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Dimethyl bisphenolate 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dimethyl bisphenolate (Compound DMB) is a natural neolignan derivative with orally active anti-tumor activity. Dimethyl bisphenolate can inhibit cancer cells proliferation, invasion and migration. Dimethyl bisphenolate can activate the p53 signaling pathway, upregulate the expression of p21 protein, inhibit the activity of the CDK1-cyclin B1 complex, and cause cells to stall at the G2/M phase. Dimethyl bisphenolate can induce ROS production, upregulate pro-apoptotic proteins Noxa and Bim, downregulate anti-apoptotic protein Bcl-2, activate caspase-9 and caspase-3, and ultimately induce cell apoptosis. Dimethyl bisphenolate can be used for research of glioblastoma[1].

IC50 & Target[1]

CDK1/cyclinB1

 

Caspase-3

 

Caspase-9

 

Bcl-2

 

Bim

 

分子量

386.35

Formula

C20H18O8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dimethyl bisphenolate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimethyl bisphenolateDrug DerivativeMDM-2/p53CDKReactive Oxygen Species (ROS)ApoptosisBcl-2 FamilyCaspaseDrug derivativeCyclin dependent kinaseInhibitorinhibitorinhibit

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Dimethyl bisphenolate
目录号：
HY-180820
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