1. 疾病领域
  2. 炎症和免疫系统疾病 泌尿生殖系统疾病
  3. 泌尿生殖系统炎症 肾脏疾病
  4. 肾炎

Nephritis  (肾炎)

肾炎是指肾脏的炎症,通常与自身免疫性疾病(例如系统性红斑狼疮 (SLE)、感染或其他潜在疾病有关。肾炎包含多种类型,包括急性肾炎、慢性肾炎、肾小球肾炎(影响肾脏滤过膜)和间质性肾炎(肾小管间隙的炎症)。弥漫增生性肾小球肾炎是儿童和青少年 SLE 患者中最常见的类型。其症状通常包括尿液外观改变、因液体潴留导致的腿部、足部或踝部肿胀,以及如果不治疗可能发展为肾衰竭。早期诊断和干预对于预防长期并发症至关重要。肾周炎是一种与肾脏周围感染相关的疾病,也可能导致严重的后遗症,例如脓肿形成、邻近器官受累或高血压。

Nephritis refers to inflammation of the kidneys, commonly associated with autoimmune diseases such as systemic lupus erythematosus (SLE), infections, or other underlying conditions. It encompasses various types including acute nephritis, chronic nephritis, glomerulonephritis (affecting kidney filters), and interstitial nephritis (inflammation in the spaces between kidney tubules). Diffuse proliferative glomerulonephritis is the most prevalent form in pediatric and adolescent SLE patients. Symptoms often include changes in urine appearance, swelling in the legs, feet, or ankles due to fluid retention, and potential progression to kidney failure if untreated. Early diagnosis and intervention are crucial to prevent long-term complications. Perinephritis, a related condition involving infection around the kidney, may also lead to serious sequelae such as abscess formation, adjacent organ involvement, or hypertension.

参考文献:

Nephritis (2):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-178850
    TJN-331 219964-53-1
    TJN-331 是一种强效且口服有效的 TGF-β1 抑制剂。TJN-331 通过抑制 TGF-β1 的产生,改善大鼠抗肾小球基底膜 (GBM) 肾炎,从而减少肾小球毛细血管外增生。TJN-331 可抑制 ddY 小鼠实验性 IgA 肾病模型中的系膜扩张。TJN-331 可用于肾炎和 IgA 肾病的研究[1][2]
    TJN-331
  • HY-177933
    mNOX-E36
    mNOX-E36 是 NOX-E36 (HY-148100) 的鼠特异性类似物,是一种抗 CCL-2 的L-RNA 适配子,可结合并中和小鼠趋化因子 CCL-2。mNOX-E36 可减少青光眼滤过手术 (GFS) 小鼠实验模型中的瘢痕形成。mNOX-E36 可改善小鼠狼疮性肾炎。mNOX-E36 可用于 GFS 和狼疮性肾炎的研究。
    mNOX-E36