2. Immunology/Inflammation Apoptosis
  3. Interleukin Related TNF Receptor
  4. Divaricatol

Divaricatol 是一种口服有效的色原酮类天然产物，是防风 (Saposhnikovia divaricata) 中的活性成分。Divaricatol 通过稳定结合 5KIR (TNF/IL-17 通路靶点)，可减少促炎因子释放，恢复免疫稳态。Divaricatol 在小鼠模型中具有镇痛作用。Divaricatol 可用于疼痛、腹泻型肠易激综合征 (IBS-D) 及气虚证的研究。

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Divaricatol

Divaricatol Chemical Structure

CAS No. : 331433-08-0

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Divaricatol 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Divaricatol is an orally active chromone natural product and an active component in Saposhnikovia divaricata. Divaricatol reduces the release of proinflammatory cytokines and restores immune homeostasis by stably binding to 5KIR, a target of the TNF/IL-17 pathway. Divaricatol exerts analgesic effects in mouse models. Divaricatol can be used in the research of pain, diarrhea-predominant irritable bowel syndrome (IBS-D) and qi deficiency syndrome[1][2][3].

体内研究
(In Vivo)

Divaricatol (1-5 mg/kg；口服) 在小鼠醋酸扭体模型中表现出强效镇痛活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ddy (Male, 4 weeks old, 24–36 g, acetic acid-induced writhing model)[1]
Dosage: 1, 5 mg/kg
Administration: p.o.
Result: Showed potent analgesic effect at oral doses of 1 and 5 mg/kg, similar to another chromone (compound 6) with the same dihydropyran-type C-ring structure.
分子量

334.32

Formula

C17H18O7
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Divaricatol 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Divaricatol331433-08-0Interleukin RelatedTNF ReceptorILTumor Necrosis Factor ReceptorTNFRinflammatory pathwaysmiceimmune homeostasisqi deficiency syndromeirritable bowel syndrome with diarrhea (IBS-D)5KIR proteinTongxie YaofangQishenbuqi capsulesInhibitorinhibitorinhibit

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目录号：
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