2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. DNK-333

DNK-333 是一种强效且平衡的双重 NK1 和 NK2 受体拮抗剂，其 IC50 值分别为 4.8 nM 和 5.5 nM。DNK-333 可阻断 Neurokinin A (NKA) (HY-P0197) 诱导的哮喘支气管收缩。

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DNK-333

DNK-333 Chemical Structure

CAS No. : 398507-81-8

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DNK-333 相关抗体

Top Publications Citing Use of Products

查看 Neurokinin Receptor 亚型特异性产品:

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NK1R NK2R NK3R

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DNK-333 is a potent and balanced dual NK1 and NK2 receptor antagonist with IC50 values of 4.8 nM and 5.5 nM, respectively. DNK-333 blocks the Neurokinin A (NKA) (HY-P0197)-induced bronchoconstriction in asthma[1].

IC50 & Target[1]

NK1R

9.2 (pkB)

NK2R

7.43 (pkB)

hNK1

4.8 nM (IC50)

hNK2

5.5 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
5.5 nM
Compound: 9 (DNK333)
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
[PMID: 11714615]
体外研究
(In Vitro)

DNK-333 在此实验中表现出强效且可逆的 NK1 和 NK2 受体拮抗活性，其 pKb/sub> 值分别为 9.2 和 7.43[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DNK-333 相关抗体:
体内研究
(In Vivo)

DNK-333 可抑制豚鼠和松鼠猴中由 NK1 和 NK2 受体激动剂诱导的支气管收缩[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

624.40

Formula

C27H25Cl2F6N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DNK-333 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DNK-333398507-81-8DNK333DNK 333Neurokinin ReceptorNK receptorTachykinin receptorNK1/NK2 receptor antagonistasthmabronchoconstrictionInhibitorinhibitorinhibit

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产品名称：
DNK-333
目录号：
HY-128537
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