2. Epigenetics
  3. Histone Methyltransferase
  4. Dot1L-IN-6

Dot1L-IN-6 是一种有效的类端粒沉默干扰体 1 (DOT1L) 抑制剂，IC50 SPA DOT1L 为 0.19 nM。

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Dot1L-IN-6

Dot1L-IN-6 Chemical Structure

CAS No. : 2565705-01-1

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Dot1L-IN-6 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dot1L-IN-6 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.19 nM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa ED50
12 nM
Compound: 9
Inhibition of DOT1L in human HeLa cells assessed as reduction in H3K79 dimethylation measured after 72 hrs by ELISA
Inhibition of DOT1L in human HeLa cells assessed as reduction in H3K79 dimethylation measured after 72 hrs by ELISA
[PMID: 31857842]
体外研究
(In Vitro)

Dot1L-IN-6 (Compound 9) is tested in cellular assays to assess the ability to inhibit the dimethylation of H3K79 in HeLa cells (ED50 H3K79me2 Elisa=12 nM) and HOXA9 gene expression in Molm-13 cells (ED50 HOXA9 RGA=170 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dot1L-IN-6 相关抗体:
体内研究
(In Vivo)

Dot1L-IN-6 (Compound 9) shows an excellent blood exposure after a single dose (100 mg/kg)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

606.99

Formula

C25H21ClF2N6O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dot1L-IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dot1L-IN-62565705-01-1Histone MethyltransferaseDOT1LH3K79lysinehistonemethyltransferaseInhibitorinhibitorinhibit

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产品名称：
Dot1L-IN-6
目录号：
HY-135129
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