2. Neuronal Signaling GPCR/G Protein
  3. Dopamine Transporter Adrenergic Receptor 5-HT Receptor
  4. DOV-102,677

DOV-102,677 是一种口服有效的三重单胺神经递质再摄取抑制剂，同时抑制多巴胺 (DAT) (IC50 = 129 nM; Ki = 222 nM)、去甲肾上腺素 (NET) (IC50 = 103 nM; Ki = 1030 nM) 和 5-羟色胺 (SERT) (IC50 = 133 nM; Ki = 740 nM) 转运蛋白。DOV-102,677 在小鼠实验中表现出显著的抗抑郁样活性和感觉运动门控调节作用。DOV-102,677 可用于研究抑郁症。

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DOV-102,677

DOV-102,677 Chemical Structure

CAS No. : 410074-75-8

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DOV-102,677 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DOV-102,677 is an orally sctive triple monoamine neurotransmitter reuptake inhibitor that simultaneously inhibits the dopamine (DAT) (IC50 = 129 nM; Ki = 222 nM), norepinephrine (NET) (IC50 = 103 nM; Ki = 1030 nM), and serotonin (SERT) (IC50 = 133 nM; Ki = 740 nM) transporters. DOV-102,677 demonstrated significant antidepressant-like activity and sensory-motor gating regulatory effects in mouse experiments. DOV-102,677 can be used for research on depression[1].

分子量

228.12

Formula

C11H11Cl2N
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DOV-102,677 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOV-102,677410074-75-8Dopamine TransporterAdrenergic Receptor5-HT ReceptorDATSLC6A3Beta ReceptorSerotonin Receptor5-hydroxytryptamine Receptorantidepressantdopaminenorepinephrineserotonintransportermicrodialysisforced swim testprepulse inhibitiontriple reuptake inhibitorInhibitorinhibitorinhibit

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目录号：
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