2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial DNA/RNA Synthesis
  4. DS-2969b

DS-2969b 是一种口服有效的 GyrB 抑制剂，具有抗菌活性。DS-2969b 对 Clostridium difficile 菌感染有效 (MIC90: 0.06 μg/mL)，其 MIC 值分别比 Fidaxomicin (HY-17580)，Metronidazole (HY-B0318) 和 Vancomycin (HY-B0671) 低 2 倍、16 倍和 32 倍。DS-2969b 可抑制 Clostridium difficile DNA 回旋酶的超螺旋活性。DS-2969b 对其他革兰氏阳性厌氧菌，包括专性厌氧菌和兼性厌氧菌，也具有抗菌活性。临床前毒理学研究表明，DS-2969b 安全且耐受性良好。

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DS-2969b

DS-2969b Chemical Structure

CAS No. : 2092352-48-0

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DS-2969b 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DS-2969b is an orally active GyrB inhibitor with antibacterial activity. DS-2969b is is active against Clostridium difficile infection (MIC90: 0.06 μg/mL), which is 2-, 16-, and 32-fold lower than those of Fidaxomicin (HY-17580), Metronidazole (HY-B0318), and Vancomycin (HY-B0671), respectively. DS-2969b inhibits the supercoiling activity of C. difficile DNA gyrase. DS-2969b also exhibits activity against other Gram-positive anaerobes, including strict and facultative anaerobes. DS-2969b is safe and well tolerated in preclinical toxicology studies[1][2].

分子量

428.94

Formula

C17H25ClN6O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DS-2969b 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DS-2969b2092352-48-0BacterialDNA/RNA SynthesisantibacterialGram-positiveanaerobesDNA gyraseInhibitorinhibitorinhibit

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