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溶解度
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动物溶解方案
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实验小贴士
"detail_base"> "detail_brief" id="pro_brief">Dydrogesterone 是口服活性的孕激素，可作用于孕酮缺乏相关疾病。
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Dydrogesterone Chemical Structure
CAS No. : 152-62-5
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| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| Free Sample (0.1 - 0.2 mg) | Apply now | ||
| 10 mM * 1 mL in DMSO |
￥653
|
In-stock | |
| 1 mg |
￥400
|
In-stock | |
| 5 mg |
￥950
|
In-stock | |
| 10 mg |
￥1500
|
In-stock | |
| 25 mg |
￥2650
|
In-stock | |
| 50 mg |
￥3950
|
In-stock | |
| 100 mg |
￥5950
|
In-stock | |
| 500 mg | 现货 | 询价 | |
| 1 g | 询价 | ||
| 5 g | 询价 |
* Please select Quantity before adding items.
"detail_rgt" id="pro_rgt"> "pro_other_forms">
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| 生物活性 |
Dydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency. |
IC50 & Target |
Progesterone Receptor[1]. |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 体外研究 (In Vitro) |
Dydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency. Although similar in molecular structure and pharmacological effects to endogenous progesterone. It is orally active at far lower doses. Its freedom from estrogenic, androgenic, anabolic, corticoid and other undesirable hormonal effects gives it additional benefits over most other synthetic progestogens.Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counteract the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. "pro-antibodies-wrapper"> "pro-related-antibodies-tit">Dydrogesterone 相关抗体: |
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| Clinical Trial |
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| 分子量 |
312.45 |
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| Formula |
C21H28O2 |
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| CAS 号 | |||||||||||||
| 性状 |
固体 |
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| 颜色 |
White to light yellow |
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| 中文名称 |
地屈孕酮 |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 溶解性数据 |
"ss-title solution-tit" id="solution-tit" style="font-style: normal">细胞实验：
"ss-vitro solution-vitro">
DMSO 中的溶解度 : 33.33 mg/mL (106.67 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO) "stock-tit">配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 请根据您的 实验动物和给药方式 选择适当的溶解方案。
以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
"a-solution-item">动物溶解方案计算器
"a-scheme">
"a-scheme-tit">请输入动物实验的基本信息：
"calculator-form c-flex-form">
"c-form-item">
"c-form-item">给药剂量 mg/kg动物的平均体重 g "c-form-item">每只动物的给药体积 μL "c-form-item">动物数量 只 "c-tip">由于实验过程有损耗，建议您多配一只动物的量 "a-scheme a-matching"> "a-matching-tit">请输入您的动物体内配方组成： "calculator-form c-flex-form" style="align-items: center; padding-bottom: 7px;justify-content: flex-start; flex-flow: row nowrap;">
%
DMSO
+
%
"c-form-item" style="display: flex; align-items: center;" data-bind="if: opCount() > 2">
+
%
Tween-80
+
%
Saline
如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
"a-scheme a-matching" style="padding-top: 0;">
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"result-tit">计算结果
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"result" style="margin-top: 15px;display: flex; flex-wrap: wrap;">
工作液所需浓度 :
mg/mL
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"result" style="display: flex; flex-wrap: wrap; margin-top: 10px;">
储备液配制方法 :
mg
药物溶于
μL
DMSO（母液浓度为 mg/mL）。
"result-tip" style="position: relative;" data-bind="if: storeConc() > 33.33">
您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。
"tooltip-panel normal-saline-div-6" style="left: 535.453px; top: 23px; position: absolute; display: none; line-height: 24px; margin-left: -40px; padding-top: 5px; margin-top: -5px;">
"tooltip-arrowup">
"tooltip-container">
免费服务热线：400-820-3792E-mail：sales@hg.y866.cn/biomolecule 技术支持电话：021-58950656 技术支持邮箱：tech@hg.y866.cn/biomolecule "result" style="margin-top: 10px; position:relative; display: flex; flex-wrap: wrap;"> 动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。 "tooltip-panel normal-saline-div-5" style="left: 315.453px; top: 49.6562px; position: absolute; display: none; line-height: 24px;"> "tooltip-arrowup"> "tooltip-container"> 将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液 连续给药周期超过半月以上，请谨慎选择该方案。
"result-tip lh24">
请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热 （超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。
|
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| 纯度 & 产品资料 |
"details_batch">
"details_info_doc">
产品使用指南 (1538 KB)
纯度: 99.88% |
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| 参考文献 |
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。
| 可选溶剂 | 浓度 溶剂体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
|---|
| DMSO | 1 mM | 3.2005 mL | 16.0026 mL | 32.0051 mL | 80.0128 mL |
| 5 mM | 0.6401 mL | 3.2005 mL | 6.4010 mL | 16.0026 mL | |
| 10 mM | 0.3201 mL | 1.6003 mL | 3.2005 mL | 8.0013 mL | |
| 15 mM | 0.2134 mL | 1.0668 mL | 2.1337 mL | 5.3342 mL | |
| 20 mM | 0.1600 mL | 0.8001 mL | 1.6003 mL | 4.0006 mL | |
| 25 mM | 0.1280 mL | 0.6401 mL | 1.2802 mL | 3.2005 mL | |
| 30 mM | 0.1067 mL | 0.5334 mL | 1.0668 mL | 2.6671 mL | |
| 40 mM | 0.0800 mL | 0.4001 mL | 0.8001 mL | 2.0003 mL | |
| 50 mM | 0.0640 mL | 0.3201 mL | 0.6401 mL | 1.6003 mL | |
| 60 mM | 0.0533 mL | 0.2667 mL | 0.5334 mL | 1.3335 mL | |
| 80 mM | 0.0400 mL | 0.2000 mL | 0.4001 mL | 1.0002 mL | |
| 100 mM | 0.0320 mL | 0.1600 mL | 0.3201 mL | 0.8001 mL |
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Dydrogesterone152-62-5地屈孕酮Progesterone ReceptorNR3C3Inhibitorinhibitorinhibit
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